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麝香注射液对急性脑梗塞患者血单核细胞CD54分子表达及可溶性血管细胞黏附分子-1水平的影响
引用本文:吴玉生,侯倩,张道杰,李学芹.麝香注射液对急性脑梗塞患者血单核细胞CD54分子表达及可溶性血管细胞黏附分子-1水平的影响[J].中国中西医结合杂志,2006,26(4):308-310.
作者姓名:吴玉生  侯倩  张道杰  李学芹
作者单位:1. 山东大学西区医院,济南,250012
2. 济南军区71939部队卫生队
3. 济南军区总医院
摘    要:目的 探讨麝香注射液对急性脑梗塞患者炎症反应的影响及临床治疗效果。方法 42例急性脑梗塞患者随机分为2组,对照组21例,采用常规药物治疗;麝香组21例,采用麝香注射液加常规药物治疗。动态观察患者入院时、病程第7天、14天时的血单核细胞CD54分子(MC-CD54)的表达、血清可溶性血管细胞黏附分子-1(sVCAM-1)水平及临床治疗结果,并与21名健康人比较。结果 两组急性期患者MC-CD54表达率、sVCAM-1水平显著升高(P〈0.01),第7天呈现峰水平,第14天时显著回落,且两项指标在第14天以麝香组为低(P〈0.01);MC-CD54表达率与sVCAM-1水平呈正相关性(P〈0.01);治疗后神经缺损程度评分以麝香组改善明显(P〈0.05);显愈率也高于对照组(P〈0.05)。结论 麝香注射液对脑梗塞炎症反应具有抑制作用,并通过这种作用,提高了疗效。

关 键 词:脑梗塞  麝香注射液  单核细胞CD54分子  可溶性血管细胞黏附分子-1  临床疗效
收稿时间:2005-06-27
修稿时间:2005-10-06

Effects of Shexiang Injection on Expression of CD54 of Mononuclear Cells and Soluble Vascular Cell Adhesion Molecule-1 in Patients with Acute Cerebral Infarction
Authors:WU Yu-sheng  HOU Qian  HANG Dao-jie
Abstract:ObjectiveTo investigate the clinical efficacy of Shexiang Injection (SI) on inflammatory reaction in patients with acute cerebral infarction (ACI). MethodsForty-two patients with ACI were randomly divided into two groups, 21 in each group. The control group treated with conventional therapy and the SI group treated with conventional therapy plus SI. Besides, 21 healthy people were arranged in the normal group for control. Expression of CD_ 54 of mononuclear cell (MC-CD_ 54) and serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined and the clinical efficacy was observed dynamically before treatment and on the 7th, 14th day of the course. ResultsLevels of MC-CD_ 54 expression and sVCAM-1 in the ACI patients increased obviously (P<0.01), reached the peak on the 7th day, and declined obviously on the 14th day in both groups, however, the lowering in the SI group was more significant than that in the control group (P<0.01); and positive correlation was shown between these two indexes (P<0.01). After treatment, score of neural defect was improved more significantly (P<0.01), and the markedly effective and curative rate was higher in the SI group than those in the control group (P<0.05), respectively. ConclusionSI could inhibit the subsequent inflammatory reaction, and thus improve the clinical efficacy of conventional therapy in treating patients with ACI.
Keywords:cerebral infarction  Shexiang Injection  mononuclear cell-CD_ 54  soluble vascular cell adhesion molecule-1  clinical efficacy
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