糖足愈疡膏对慢性糖尿病足溃疡患者终点事件的影响

目的 评价糖足愈疡膏治疗慢性糖尿病足溃疡的有效性和安全性。

Effect of Tangzu Yuyang Ointment on the Outcome Event of Patients with Chronic Diabetic Foot Ulcers

Objective To assess the efficacy and safety of Tangzu Yuyang Ointment（TYO） for treatment of chronic diabetic foot ulcers.Methods Fifty-seven patients with chronic diabetic foot ulcers of Wagner′s ulcer grade 1 to 3 were randomly assigned to the control group（29 cases） and the treatment group（28 cases）.Patients in the control group received the standard wound therapy（SWT）,while those in the treatment group received SWT plus TYO.The ulcer healing rate,the ulcer improvement rate and the incidence of adverse events were compared between the two groups.Totally 48 patients finished the final follow-ups and entered the data analysis.Results The ulcer improvement rate was 79.2% in the TYO group and 41.7% in the SWT group（P=0.017） at the 12th week,and 91.7% vs.62.5%（P=0.036） at the 24th week.There was no statistical difference in the ulcer healing rate and the incidence of adverse events between the two groups at week 4,12,and 24,respectively.The ulcer healing time was 96±56 days in the TYO group and 75±53 days in the SWT group,showing insignificant difference（P=0.271）.Conclusion TYO plus SWT was more safe and effective than SWT alone in the treatment of chronic diabetic foot ulcers.