| 中药对胃粘膜合成前列腺素的临床及实验研究 |
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| 引用本文： | 王长洪,王艳红,周莹,樊新亚,高学武,陈山泉.中药对胃粘膜合成前列腺素的临床及实验研究[J].中国中西医结合杂志,1994,14(9):528-530. |
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| 作者姓名： | 王长洪 王艳红 周莹 樊新亚 高学武 陈山泉 |
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| 作者单位： | 沈阳军区总医院 |
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| 摘 要： | 以益气健脾、清热解毒中药治疗６２例消化性溃疡及糜烂性胃炎，观察治疗前后胃粘膜ＰＧｓ的动态变化。结果显示ＰＧＥ２治疗后与健康人接近（Ｐ＞０．０５），ＰＧＦ１α、６－ｋｅｔｏ－ＰＧＦ１α治疗后显著升高（Ｐ＜０．０１），而ＴＸＢ２较治疗前显著下降（Ｐ＜０．０１）。湿热型ＴＸＢ２较其他型显著升高（Ｐ＜０．０１）。中药对吲哚美辛诱发的大鼠实验性溃疡有明显保护作用，对ＰＧｓ的影响与临床观察一致。
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| 关 键 词： | 前列腺素 健脾益气 清热解毒 |
Clinical and Experimental Study on Effect of Chinese Herbal Drugs in Producing postglandin of Gastric Mucosa |
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| Authors: | Wang Chang-hong Wang Yan-hong Zhou Ying |
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| Institution: | Wang Chang-hong,Wang Yan-hong,Zhou Ying,et al Military General Hospital of Shen yang,Sheng yang 110015) |
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| Abstract: | The PG content were determined in 62 cases with peptic ulcer and erosive gastritis before and after the treatment of Chinese herbal drugs.The value of PGE2,PGFla,6-keto-PGFla and TXB2 were 96.25±28.51, 14.24±13.26, 10.72±9.14 and 16.51±12.24 pg/mg respectively before the treatment and were 121.42±30.02, 18.59±18.40, 18.79±12.61,8.29±6.27 pg/mg respectively after the treatment.6-keto-PGFla was significantly increased(P<0.01), TXB2 was decreased(P<0.01),but there were on significant changes in PGE2 and PGFla.Experimental study also showed that Chinese Herbal drugs played an important role in protecting indomethacine induced ulcer rats. |
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| Keywords: | Jianpi Yiqi Qingre Jiedu prostaglandins indomethacine |
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