| 活血化瘀、益气养阴法对实验性肺纤维化LPO和SOD的影响 |
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| 引用本文： | 刘晓滨,姜晓姝,周亚滨,王刚.活血化瘀、益气养阴法对实验性肺纤维化LPO和SOD的影响[J].中国中西医结合杂志,1994,14(12):733-735. |
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| 作者姓名： | 刘晓滨 姜晓姝 周亚滨 王刚 |
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| 作者单位： | 黑龙江中医学院呼吸病研究所，哈尔滨医科大学病理生理教研室 |
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| 摘 要： | 本研究通过小鼠肺纤维化模型的复制及中药复方－肺纤维（ＦＸＫ）对小鼠肺纤维化的防治，动态观察肺组织脂质过氧化物（ＬＰＯ）含量和超氧化物歧化酶（ＳＯＤ）活性变化。结果显示：肺泡炎阶段ＬＰＯ含量明显升高（Ｐ＜０．０１），ＳＯＤ活性明显下降（Ｐ＜０．０１）。肺纤维化形成时ＬＰＯ含量无显著变化（Ｐ＜０．０５），而ＳＯＤ活性显著升高（Ｐ＜０．０１）。ＦＸＫ降低ＬＰＯ含量明显优于抗氧化剂维生素Ｅ，并有提高ＳＯＤ
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| 关 键 词： | 肺纤维化 过氧化脂质 中药疗法 |
Effect of Promosing Blood Circulation to Remove Stasis and Supplementing Qi and Nourishisg Yin on the Lipid Peroxide and Superoxide Dismutase during Experimental Pulmonary Fibrosis |
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| Authors: | Liu Xiao-bin Jiang Xiao-shu Zhou Ya-bin |
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| Abstract: | The preventive and therapeutic effect of the traditional Chinese compound medicine Feixiankang(FXK) on the mice pulmonary fibrosis formation have been studied with the mice model. The level of LPO and the activity of SOD in the mice lung showed that LPO increased remarkably (P<0.01), while the activity of SOD decreased significantly (P<0.01) during the alveolar pneumonia period, although the LPO content had no dignificant change (P<0.01) during experimental pulmonary fibrosis formation. In addition, the effect of FXK on the reducing of LPO was much stronger than that of the antioxidative agent Vitamin E. Also, FXK could improve the activity of SOD. |
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| Keywords: | pulmonary fibrosis lipid peroxidation superoxide dismutase Chinese drugs treatment |
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