中药制剂对胆石病患者胆汁成分的影响

选择５１例行胆道手术胆总管置Ｔ管引流患者，分三组观察服药前后胆汁中主要成分的变化。结果：胆胰和胃冲剂组，服药后胆酸第２、３天显著升高（Ｐ＜０．０１），胆红素、粘蛋白第１、２、３天显著降低（Ｐ＜０．０１）。溶石散组，服药后胆酸第３天显著增高（Ｐ＜０．０５），胆红素第２、３天显著降低（Ｐ＜０．０１，Ｐ＜０．０５）。对照组变化不显著（Ｐ＞０．０５）。胆酸与胆红素，胆酸与胆固醇比值服药组呈动态性升高。实验

Effect of Chinese Herbal Preparation on Major Constitnents of Bile of Gallstones Patients

From 1991 to 1993,51 patients in 3 groups who had received biliary operation with T tube drainage were selected for observation of dynamic change in bile acid,bilirubin,cholesterol and mucin in the bile within 3 days after taking the Danyihewei granule(DYHW) and Rongshisan(RSS).Result showed that in DYHW group the bile acid increased significantly on the 2 nd and 3 rd day(P<0.01),along with significant lowering of bilirubin(P<0.01) and mucin(p<0.05,P<0.01) in lst through 3 rd day.In the RSS group the bile acid remarkably increased on the 3 rd day (P<0.05)with significant reduction of bilirubin(P<0.01) on 2 nd and 3 rd day. The control group showed no remarkable change.The bile acid/bilirubin and bile acid/cholesterol ratios all had a dynamic increase with 3 days in treated group. Whereas the control group remained unchanged.Therefore the DYHW and RSS were able to produce a strong inhibitory effect on stone-forming bile through regtilation of liver and discharge of bile.