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黄芪注射液对充血性心力衰竭患者免疫功能的影响
引用本文:刘志高,熊正明,余细勇.黄芪注射液对充血性心力衰竭患者免疫功能的影响[J].中国中西医结合杂志,2003,23(5):351-353.
作者姓名:刘志高  熊正明  余细勇
作者单位:1. 华中科技大学同济医学院附属梨园医院心内科,武汉,430077
2. 广东省心血管病研究所临床药理室
摘    要:目的:研究黄芪注射液对充血性心力衰竭(CHF)患者体液免疫(IgG、IgA、IgM)、细胞免疫(T细胞亚群)及可溶性白细胞介素-2受体(sIL-2R)的影响。方法:将62例属NYHA心功能分级为2~4级的住院患者随机分为两组。在西医常规治疗的同时,治疗组加用黄芪注射液30ml(相当于生药60g)加入5%葡萄糖注射液500ml中静脉滴注。每天1次;对照组用硝酸甘油10mg加入5%葡萄糖注射液500ml中静脉滴注,每天1次。疗程均为20天。两组治疗前后均采血测定IgG、IgA、IgM、T细胞亚群和sIL-2R,同时进行临床疗效评价。结果:治疗组临床心功能改善显效率及总有效率分别为25.8%、74.2%,明显优于对照组(P<0.05,P<0.01)。两组治疗后的左室射血分数(LVEF)和收缩末期容积(ESV)较治疗前均有明显改善(P<0.05,P<0.01),且治疗组优于对照组(P<0.05)。治疗后治疗组的CD4和CD4/CD8比值上升(P<0.05),sIL-2R明显下降(P<0.05),IgG、IgA明显下降(P<0.05);对照组各项指标无明显变化(P>0.05)。结论:黄芪注射液能够改善患者的免疫功能,可作为治疗CHF的重要辅助药物。

关 键 词:黄芪注射液  充血性心力衰竭  免疫功能  细胞免疫  可溶性白细胞介素-2受体
修稿时间:2002年9月17日

Effect of Astragalus Injection on Immune Function in Patients with Congestive Heart Failure
Authors:LIU Zhi gao  XIONG Zheng ming and YU Xi yong
Abstract:OBJECTIVE: To study the effect of Astragalus Injection (AI) on the humoral immunity (IgG, IgA and IgM), cellular immunity (T-lymphocyte subsets) and soluble interleukin-2 receptor (sIL-2R) in patients with congestive heart failure (CHF). METHODS: Sixty-two in-patients with CHF, whose heart function belonged to NYHA grade II-IV, were randomly divided into two groups. The treated group was treated with AI 30 ml (equivalent to 60 g crude drug), and the control group was treated by nitroglycerine injection 10 mg, the drugs were administered respectively by adding in 5% glucose solution 500 ml for intravenous dripping, once a day, 20 days as one therapeutic course. Venous blood from cubital vein was collected before and after treatment to detect the IgG, IgA, IgM, T-lymphocyte subsets and sIL-2R, and the clinical effect of treatment was evaluated. RESULTS: The clinical heart function markedly improved rate and total effective rate in the treated group was 25.8% and 74.2% respectively, significantly better than those in the control group respectively (P < 0.05 or P < 0.01), the left ventricular ejecting fraction (LVEF) and end syctolic volume (ESV) were improved in both groups (P < 0.05, P < 0.01), and the improvement in the treated group was superior to that in the control group (P < 0.05). In the treated group after treatment, the CD4 level and CD4/CD8 ratio increased (P < 0.05), levels of sIL-2R, IgG and IgA lowered (P < 0.05) significantly, while those in the control group were not changed significantly (P > 0.05). CONCLUSION: AI could improve the immune function of CHF patients, and can be taken as an important auxiliary treatment for CHF.
Keywords:Astragalus Injection  congestive heart failure  grading of heart function  T  lymphocyte subsets  humoral immunity  soluble interleukin  2 receptor  
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