冠心病气虚、气阴两虚证的心功能特点及生脉注射液的效应观察

本研究应用心阻抗微分图和收缩时间问期(STI)检测气虚、气阴两虚型冠心病患者的心功能,并观察生脉注射液对这两种证型冠心病的心血管效应。与气虚型相比气阴两虚型冠心病患者 Q-ZI 显著延长(P<0.01),PEP/LVET 增大(P<0.05),HI 显著减小(P<0.001)。注射生脉注射液后,气阴两虚型患者 dz/dt max、血管顺应性(C)明显增大(P<0.05),HI 增加的幅度大于气虚型患者。说明冠心病证型的不同和心功能减退的程度有一定的关系,不同证型对生脉注射液的反应性亦有所差异。

Cbaracteristic of Cardiac Function and Effect of Shengmai Injection on Qi Deficiency and Qi-Yin Deficiency in Patients with Coronary Heart Disease

Deficiency of Qi(DQ)and deficiency of both Qi and Yin(DQY)are most common deficiency syndrome in TCM classification of coronary heart disease(CHD)patients.Comparison of cardiac function between DQ and DQY group showed that Q-ZI in DQY group was significantly longer than that in DQ group(P<0.01),PEP/LVET ratio in DQY was significantly higher than that in DQ group (P<0.05),and HI in DQY group was much lower than that in DQ group(P<0.001).The 3 parameters of heart failure patient in DQY group were markedly different from those in DQ group,but in non-heart failure patients only HI was different between DQY and DQ group.It suggested that in CHD patients the left ventricular function in DQY group is lower than that in DQ group,especially in patients with heart failure.After intravenous administration of Shengmai Injection,the majority of cardiac functional parameters improved in various degrees.However,in DQ group,the dz/dt max and compliance(C)had no evident changes(P>0.05),in contrast with DQ group there were some significant changes in DQY group(P<0.05).It seems that the effect of improving dz/dt max and C was better in DQY group than in DQ group after intravenous Shengmai Injection.After the treat- ment.HI was from 13.84±3.16 to 14.88±3.80 in DQ group and from 10.71±3.22 to 13.32±3.31 in DQY group There were significant difference between these two groups(P<0.01).The increase of HI in DQY was higher than that in DQ group.