大蒜素对不同中医证型不稳定性心绞痛的作用及与血脂和GMP-140的关系

目的：观察大蒜素注射液对不稳定性心绞痛的临床疗效及与中医证型的关系。方法：将５５便不稳定性心绞痛患者随机分为治疗组（３４例）和对照组（２１例），每组依中医辨证再分为偏寒和偏热型及重度瘀血和轻度瘀血型。治疗组和对照组分别每天静脉滴注大蒜素（６０ｍｇ和硝酸甘油５ｍｇ，疗程１０天。根据疗程前后症状和心电图变化评定疗效，并测定血脂、脂蛋白、载脂蛋白和血小板α颗粒膜蛋白（ＧＭＰ－１４０）。结果：大蒜素组疗效

Effect of Garlicin on Unstable Angina Pectoris and Its Relationship with Blood Lipid and GMP-140

Objective: To observe the clinical effect of Garlicin on unstable angina pectoris (UAP) and to explore the relationship between Garlicin's effect and Syndrome Differentiation of TCM. Methods: Fifty five patients of UAP were divided randomly into the Garllcin group (34 cases) and the control group (21 cases) and classified based on Syndrome Differentiation of TCM into Cold Syndrome type, Heat Syndrome type, severe blood stasis (SBS) type or mild blood stasis (MBS) type. Garlicin 60 mg or nitroglycerin 5 mg were given to the two groups respectively by intravenous drip for 10 days as one therapeutic course. The curatic effect was evaluated by changes of symptoms and electrocardiogram, and some indexes, such as blood lipid, lipoprotein, apolipoprotein and GMP 140 among different groups and types were compared Results: The difference of effective rate between the Garlicin group and the control group was insignificant. In the Garlicin group, the effective rate of Cold Syndrome type was higher than that of Heat Syndrome type (P<0 01), and HDL/LDL ratio and apoA 1 level raised markedly in the former type (P<0 05) while an oppositive trend revealed in the Heat Syndrome type. Garlicin showed a higher effect on SBS type than that on MBS type and cause GMP 140 of the MBS type decreased obviously. Conclusion: Garlicin is effective on UAP patients and its effect was more evident on those with Cold Syndorme type or SBS type. Its mechanism may be related to its effect in improving blood lipid and enhancing activation of platelet.