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健乳灵治疗乳腺增生病临床和实验研究
引用本文:黄霖,潘朝明,罗崇谦,文端成,黄月玲,韦永芳.健乳灵治疗乳腺增生病临床和实验研究[J].中国中西医结合杂志,1999,19(6):329-331.
作者姓名:黄霖  潘朝明  罗崇谦  文端成  黄月玲  韦永芳
作者单位:广州医学院第一附属医院中医科,广州医学院实验动物中心
摘    要:目的:探讨健乳灵治疗乳腺增生病的疗效和对性激素的调节机理。方法:观察健乳灵治疗前后乳腺增生病的临床变化及血清性激素变化。动物实验通过病理,电镜,放射免疫等法观察健乳灵治疗乳腺增生病的疗效和性激素的变化。结果:健乳灵治疗乳腺增生病,治疗组临床治愈率为725%,总有效率为90.8%,与对照组比较有显著性差异,而且有调节性激素水平的作用;雌二醇和垂体催乳素明显降低;而孕酮和睾酮则有回升;

关 键 词:健乳灵片  乳腺增生病  性激素  治疗

Clinical and Experimental Study of Jianruling in Treating Hyperplasia of Mammary Gland
Authors:Huang Lin  Pan Chaoming  Luo Chongqian  
Abstract:Objective: To observe the therapeutic effect of Jianruling (JRL) on hyperplasia of mammary gland (HMG) and to explore its mechanism in regulating sex hormones. Methods: Clinical changes of HMG were observed and serum sex hormones measured before and after JRL treatment. In experimental study, the effect of JRL was estimated by using electron microscope, pathologic and radioimmunoassay. Results: JRL could not only cure HMG, but also regulate the sex hormone secretion both in HMG patients and in rats. Clinical study showed that the clinical cure rate was 72.5%, and the total effective rate was 90.8%, it demonstrated a significant difference in comparing with the control group, P<0 01. The estradiol and prolactin levels of patients lowered significantly after JRL treatment, P<0 05, while progestogen and testosterone increased significantly, P<0 05, but no significantly change of follicle stimulating hormone and luteinizing hormone was found. JRL showed marked effect in treating and preventing experimental HMG in rats, it could modulate the secretive function of sex hormone, and improve the construction of mammary gland. Conclusion: JRL has significant effect in treating HMG, it can adjust the endogenous sex hormone level, delay the development of chronic cystic hyperplasia of mammary gland.
Keywords:Jianruling  hyperplasia of mammary gland  sex hormone  rat
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