银杏叶制剂治疗肺间质纤维化的实验研究 |
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引用本文: | 陈建,何冰,刘新民,王海斌,章巍,张英.银杏叶制剂治疗肺间质纤维化的实验研究[J].中国中西医结合杂志,2000,20(6):441-443. |
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作者姓名: | 陈建 何冰 刘新民 王海斌 章巍 张英 |
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作者单位: | 北京医科大学第一医院呼吸科,北京 |
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基金项目: | 卫生部基金!96-1-266 |
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摘 要: | 目的:探讨银杏叶制剂(百路达)对博莱霉素A5所致大鼠肺间质纤维化的治疗作用及机制。方法:对博莱霉素A5所致大鼠肺间质纤维化为模型,观察百路达治疗后病理、胶原蛋白、核因子kB活性、转化生长因子-β(TGF-β)mRNA表达及蛋白水平的变化。结果:百路达治疗组肺泡炎、纤维化病变均较博莱霉素模型组减轻(P〈0.05),其胶原蛋白含量较模型组减少(P〈0.01),百路达治疗组1周肺泡巨噬细胞核因子kB(N
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关 键 词: | 肺纤维化 银杏叶制剂 中医药疗法 实验研究 |
Experimental Study on Effect of Folium Ginkgo Biloba in Treating Pulmonary Interstitial Fibrosis in Rats |
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Authors: | CHEN Jian HE Bing LIU Xinmin et a |
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Institution: | Department of Pulmonary Medicine, First Hospital of Beijing Medical University, Beijing (100034). |
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Abstract: | 0bjective: To evaluate the therapeutic effect and mechanism of folium Ginkgo biloba (FGB) in treating pulmonary interstitial fibrosis (PIF) induced by bleomycin in rats. Methods: PIF models of bleomycin-A5-in- duced pulmonary fibrosis were established in rats, they were treated by Bailuda, a preparation of FGB, and the pathological changes, collagen protein level, nuc1ear factor kB(NF-kB) activity, transforming growth factor 9 (TGF-8) mRNA expression and protein level of the lung tissue were measured. Results: In the Bailuda treated group after treatment, amelioration of the pulmonary alveolitis and fibrosis were shown in pathological section (P < 0. O5 ) and collagen protein content was lesser (P < O. 01 ) as compared with those in the model control group. After l week of Bailuda treatment, the NF-kB activity of pulmonary alveola macrophage lowered by 47.3 %, and levels of TGF-8 mRNA expression and protein were all decreased (P < O. O5 ). Conclusions: Bailuda has definite effect in treating PIF. The mechanism may be through inhibiting the activity of NF-kB, decreasing TGF-9 mRNA expression and protein, so as to ameliorate the inflammation and fibrosis. |
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Keywords: | pulmonary fibrosis folium Ginkgo biloba nuclear factor |
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