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参麦注射液对晚期癌症患者sIL-2R、LAK及NK细胞活性影响
引用本文:冯培芳,刘鲁明,沈玉英. 参麦注射液对晚期癌症患者sIL-2R、LAK及NK细胞活性影响[J]. 中国中西医结合杂志, 1995, 15(2): 87-89
作者姓名:冯培芳  刘鲁明  沈玉英
作者单位:浙江省中医院;浙江省中医院;浙江省中医院
摘    要:本研究测定了60例晚期癌症患者用参麦注射液治疗前后血清可溶性白细胞介素-2受体、淋巴因子活化的杀伤细胞和天然杀伤细胞的活性,并以40例正常人为对照。结果显示:治疗前癌症患者sIL-2R显著升高,LAK细胞与NK细胞活性显著减低。而上述变化在胃癌、肠癌与肺癌之间无显著差异。治疗后3种癌症患者的sIL-2R均有显著下降,LAK与NK细胞活性均有显著增强。而sIL-2R与LKA及NK细胞活性之间无相关性

关 键 词:参麦注射液  晚期    白细胞介素2  自然杀伤细胞

Effect of Shenmai Injection on sIL-2R NK and LAK Cells of Patients with Advanced Carcinoma
Feng Pei-fang,Liu Lu-ming and Shen Yu-ying. Effect of Shenmai Injection on sIL-2R NK and LAK Cells of Patients with Advanced Carcinoma[J]. Chinese journal of integrated traditional and Western medicine, 1995, 15(2): 87-89
Authors:Feng Pei-fang  Liu Lu-ming  Shen Yu-ying
Abstract:Serum interleukin-2 receptor(sIL-2R) level activities of natural killer cell(NK) and lymphokine activated killer cell(LAK) cells were determined in 60 patients with.advanced carcinoma(AC) before and after treatment with Shenmai injection(SMI),40 healthy persons were taken as non-carcinoma control(NC).The results showed that: Serum slL-2R level in AC were much higher than those in NC (p<0.05) and activities of NK and LAK cells in AC were much lower than those in NC(P<0.05)before treatment. There was no significant difference among gastric cancer,colonic carcinoma and lung cancer (P>0.05). After treatment with SMI we also found that the level of slL-2R in all patients were obviously lower (P<0.05) while the activity of NK and LAK cells were significantly higher than that prior treatment(p<0.05). Linear correlation was not found between slL-2R and NK, LAK cells.These data suggested that the immune function was compromised in AC. The mechanism of the inhibitory effect of SMI on carcinoma might be related to the activity of biological response modifier.
Keywords:shenmai injection  advanced carcinoma  soluble interleukin-2 receptor  lymphokine activated killer cell  natural killer cell
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