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胃痛灵保护胃粘膜作用及对胃溃疡愈合质量的影响
引用本文:鄢顺琴,凤良元,苏英豪,陈向涛,许家林.胃痛灵保护胃粘膜作用及对胃溃疡愈合质量的影响[J].中国中西医结合杂志,1995,15(10):612-614.
作者姓名:鄢顺琴  凤良元  苏英豪  陈向涛  许家林
作者单位:安徽中医学院;安徽中医学院;安徽医科大学;安徽中医学院;安徽医科大学
摘    要:采用无水乙醇、0.6NHCl、0.6NNaOH等诱发大鼠急性胃溃疡,并用冰醋酸引发慢性溃疡模型,观察中药胃痛灵对胃粘膜的保护作用。用粘液组织化学染色、AgNOR染色和免疫组化染色对大鼠愈合性胃溃疡再生粘膜进行定量观察,用胃痛灵治疗后和自然愈合的溃决粘膜作比较。

关 键 词:胃痛灵  胃溃疡  胃粘膜  再生粘膜

Protective Effect of "Wei Tong Ling" on Gastric Mucosa and Influence on Quality of Gastric Ulcer Healing
Authors:Yan Shun-qin  Feng Liang-yuan  Su Ying-hao
Abstract:The acute gastric ulcer rat models were induced by dehydrated alcohol, 0.6 N hydrochloric acid and 0. 6 N sodium hydroxide, and the chronic gastric ulcer rat models were established by means of acetic acid, the protective effect of Chinese medicine "Wei Tong Ling"(WTL) on gastric mucous membrane was studied. Using histochemical mucin stain, AgNOR stain and immunohistochemical technique the regenerated mucosa of healed gastric ulcer induced by acetic acid in rats was observed quantitatively. They were compared with that of WTL. The results showed that the regenerated mucosa of healed gastric ulcer might be the morphological basis for the recurrence of gastric ulcer and be associated with canceration. WTL could not only accelerate the healing of ulcer but also raise the quality of gastric ulcerous healing which was beneficial for the prevention of ulcer recurrence and canceration. The protective effect of WTL on gastric mucosa was comfirmed by various assays.
Keywords:Wei Tong Ling  gastric ulcer  gastric mucosa  regenerated mucosa
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