还脑益聪胶囊对老年轻度认知障碍的影响

目的 观察还脑益聪胶囊对老年轻度认知障碍的影响。方法 将62例老年轻度认知障碍患者按随机数字表法随机分为治疗组与对照组各31例，治疗组服用还脑益聪胶囊，每次3粒，每日3次；对照组服用喜得镇，每次3粒，每日3次，连续服用2个月为1个疗程。观察两组患者认知疗效指数、量表(CCSE、FQA、MMSE)积分值、中医症状积分、生活质量、大脑动脉血流及血液流变学指标的变化情况。结果 认知功能疗效，治疗组30例(脱落1例)总有效率为83．33％，对照组29例(脱落2例)总有效率为48．28％，两组比较差异有显著性(U=2．36，P<0．05)；纳入意向性分析，即治疗组脱落1例计为无效，对照组脱落2例计为有效，则治疗组总有效率为80．65％，对照组总有效率为51．61％，两组疗效比较差异亦有显著性(u=2．02，P<0．05)。治疗组认知量表CCSE、FAQ及MMSE的积分值治疗后均明显提高(P<0．05或P<0．01)，与对照组比较差异亦均有显著性(P<0．05)。中医症状积分值，治疗组治疗后有显著降低(P<0．01)，与对照组比较差异有显著性(P<0．05)。生活质量的各方面指标积分均有显著改善，多项优于对照组(P<0．05或P<0．01)，大脑动脉的平均血流量有显著改善(P<0．01，P<0．05)，并优于对照组(P<0．01，P<0．05)，同时对大脑动脉的阻力指数也有显著改善。治疗组还能改善血液流变学各项指标，与对照组比较差异有显著性(P<0．01，P<0．05)。结论 还脑益聪胶囊治疗老年轻度认知障碍有较好疗效，安全、无毒副反应。

Effect of Huannao Yicong Capsule on Senile Mild Cognitive Impairment

OBJECTIVE: To observe the effect of Huannao Yicong capsule (HYC) on senile mild cognitive impairment. METHODS: Sixty-two patients were randomly divided into two groups, the 31 patients in the treated group were treated with HYC 3 capsules, 3 times daily, and the 31 in the control group with Hydergin 3 tablets, 3 times daily. Treatment for two successive months was a therapeutic course. The changes of cognitive effect index (CEI), integral of measuring scale (CCSE, FQA and MMSE), TCM Syndrome scoring, quality of life (QOL), cerebral arterial blood flow (CBF) and hemorrheologic parameters in the two groups were observed. RESULTS: The total effective rate of treatment in improving cognition in the 30 patients of the treated group (with one case lost) was 83.33%, while that in the 29 patients of the control group (with two cases lost) was 48.28%, the difference between them was significant (u = 2.36, P < 0.05). Intent-to-treat analysis, namely, the case lost in the treated marked as ineffective and those in the control group as effective, showed the total effective rate in the two groups was 80.65% and 51.61% respectively, which also showed significant difference (u = 2.02, P < 0.05). In the treated group after treatment, the integrals of CCSE, FAQ and MMSE significantly increased (P < 0.05 or P < 0.01), the TCM Syndrome scoring decreased (P < 0.01), the scoring of QOL significantly improved, the mean BBF increased (P < 0.05 or P < 0.01), and the cerebral arterial resistance index improved significantly. All these improvements in the treated group were significantly higher than those in the control group respectively (P < 0.05). Besides, the hemorrheologic parameters in the treated group were improved, most of them were better than those in the control group (P < 0.05 or P < 0.01). CONCLUSION: HYC has good therapeutic effect on senile mild cognitive impairment, it is safe without any adverse reaction.