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麝香保心丸减少高脂血症对动脉壁损害作用的实验研究
引用本文:罗心平,李勇,范维琥,张高峰,张军,施海明,王彩萍,王受益,戴瑞鸿.麝香保心丸减少高脂血症对动脉壁损害作用的实验研究[J].中国中西医结合杂志,1998,18(8):486-489.
作者姓名:罗心平  李勇  范维琥  张高峰  张军  施海明  王彩萍  王受益  戴瑞鸿
作者单位:上海医科大学华山医院心内科!上海200040,上海医科大学华山医院心内科!上海200040,上海医科大学华山医院心内科!上海200040,上海医科大学华山医院心内科!上海200040,上海医科大学华山医院心内科!上海200040,上海医科大学华山医院心内科!上海200040,上海医科大学华山医院心内科!
摘    要:目的:观察麝香保心丸能否减少高脂血症对动脉壁的损害作用。方法:喂饲胆因醇饲料8周形成实验性高胆因醇血症,部分动物于第7周开始加用麝香保心丸喂养2周;在不同的时间测量动物血脂浓度、心电图改变、血清超氧化物歧化酶(SOD)水平、动脉壁的光镜及电镜改变,以说明麝香保心丸对动脉血管壁的保护作用。结果:麝香保心丸能显著抑制血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平的上升;增加血清SOD的浓度

关 键 词:麝香保心丸  高脂血症  动脉壁  动脉粥样硬化

Experimental Study on Reducing Effect of Shexiang Baoxin Pill from Damage of Arterial Wall Caused by Hyperlipemia
Authors:Luo Xinping  Li Yong  Fan Weihu  Huashan Hospital  Shanghai Medical University  Shanghai
Abstract:Objective: To study the protecting effect of Shexiang Baoxin Pill (SXBXP) on arterial wall in hyperlipemia rabbit model. Methods: Thirty six male, New Zealand rabbits were randomized into three groups: control group, fed with common diet for 8 weeks: Hypercholesterolemia group (HC) and SXBXP group (SX), fed with 1% cholesterol and 3% lard diet for 8 weeks. In SX group, SXBXP was iven from 7th week for 2 weeks. The plasma levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured at the first, 6th and the 8th week of experiment. Serum superoxide dismutase (SOD) and electrocardiography (ECG) were also evaluated at the 8th week. Light microscopy and transmission electron microscopy were adopted to assess the degree of pathologic damage of arterial wall. Results: SXBXP could reduce the levels of serum TC and LDL-C, as compared with the HC group, P<0 05. It could also reduce the extent of atherosclerotic lesion and the severity of intimal proliferation. Conclusion: SXBXP has the effect of inhibiting developement of experimental atherosclerosis.
Keywords:Shexiang Baoxin Pill  hypercholesterolemia  atherosclerosis  superoxide dismutase
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