重组炙甘草汤配合小剂量糖皮质激素治疗特发性血小板减少性紫癜的临床观察

目的探讨重组炙甘草汤配合小剂量糖皮质激素(简称激素)治疗特发性血小板减少性紫癜(ITP)的临床价值。方法用半随机组合的方法将43例患者分成两组，治疗组(21例)用重组炙甘草汤配合小剂量激素治疗，对照组(22例)用常规剂量激素治疗。结果临床疗效治疗组优于对照组(P＜0.05)。血小板计数(×109／L）治疗组治疗前为36.29±9.70，治疗后为95.14±18.26(P＜0.01)；对照组治疗前为37.31±9.29，治疗后为77.73±21.96(P＜0.01)，升高血小板数治疗组优于对照组(P＜0.01)；副反应治疗组明显小于对照组(P＜0.01)。结论重组炙甘草汤配合小剂量激素治疗ITP副反应少，且疗效可靠。

Clinical Study on Effect of Recombinant Roasted Licorice Decoction Combined with Low Dose Glucocorticoids in Treating Idiopathic Thrombocytopenic Purpura

OBJECTIVE: To explore the clinical effect of recombinant roasted licorice decoction (RRLD) combined with low-dose glucocorticoids (GC) in treating idiopathic thrombocytopenic purpura (ITP). METHODS: Forty-three patients were divided semi-randomly into the treated group (n = 21) and the control group (n = 22), the former was treated with RRLD plus low-dose GC, and the latter was treated mainly with normal dosage of GC. RESULTS: The total effective rate of the treated group was better than that of the control group, the difference between these two groups was significant (P < 0.05). After treatment the platelet count in the treated group arose from (36.29 +/- 9.70) x 10(9)/L to (95.14 +/- 18.26) x 10(9)/L, while in the control group from (37.31 +/- 9.29) x 10(9)/L to (77.73 +/- 21.96) x 10(9)/L, the RRLD was superior to nat of GC in raising platelet count, the difference between them was also significant (P < 0.01). The treated group was lower obviously than the control group in adverse reaction (P < 0.01). CONCLUSION: The efficacy of RRLD plus low-dose GC is reliable in treating ITP, with less adverse reaction.