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麝香保心丸治疗冠心病心绞痛的临床观察
引用本文:王受益,戴瑞鸿,金椿,罗海明,陈曙霞,陈美芳,徐济民,郑慧君,荣烨之,赵美华,胡婉英,徐雅民.麝香保心丸治疗冠心病心绞痛的临床观察[J].中国中西医结合杂志,1996,16(12):717-720.
作者姓名:王受益  戴瑞鸿  金椿  罗海明  陈曙霞  陈美芳  徐济民  郑慧君  荣烨之  赵美华  胡婉英  徐雅民
作者单位:上海医科大学华山医院,上海第二医科大学仁济医院,上海市第九人民医院,上海第二医科大学新华医院,上海中医药大学曙光医院,上海东方医院
摘    要:将210例冠心病心绞痛患者随机分为麝香保心丸治疗组(110例)和消心痛对照组(100例)。两组在年龄、心绞痛分型、合并病变及心功能分级分布均相仿,前者给予麝香保心丸2丸,每日3次口服;后者给予消心痛5 ̄10mg,每日3次口服,经2周治疗,二药均可显著降低心绞痛发作频率和硝酸甘油日耗量,并显著改善心电图ST压低总和(ΣST)改变。但是总的症状疗效、心电图疗效和不良反应则麝香保心丸明显优于消心痛。即症

关 键 词:冠心病  心绞痛  麝香保心丸  中医药疗法

Clinical Observation of Shexiang Baoxinwan for Treatment of Coronary Heart Disease with Angina Pectoris
Authors:WANG Shou-yi  DAI Rui-hong  JIN Chun  
Abstract:Two hundred and ten patients with angina pectoris in coronary heart disease were randomly assigned to receiving Shexiang Baoxinwan(SXBXW),the protecting heart musk pills(110 patients),or receiving isosorbide dinitrate(100 patients) for 2 weeks. They were well matched for age,afiginal types,complications and cardiac functional grading.The results demonstrated that both agents not only could reduce significantly the frequencies of anginal episodes and the consuniption amount of nitroglycerin per day, they also could result in significant improvement of the ST segment depression in electrocardiogram.Furthermore,the SXBXW had better efficacy than that of isosorbide dinitrate in the total improvement rate of symptoms of angina pectoris and of ECG,and in the reduction of incidence of headache,ie 90.0% vs.76.%;58.6% vs.40.8%;0.9% vs.17%,respectively(P<0.05 or P<0.01).In addition,the onset of action of both agents was rapid,within five minutes(83.4% in patients using SXBXW vs.86.3% in control group,P>0.05).
Keywords:coronary heart disease  angina pectoris  Shexiang Baoxinwan(protecting heart musk pill)  isosorbide dinitrate
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