生脉散对急性病毒性心肌炎患者血清脂质过氧化物的影响 |
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引用本文: | 赵美华,荣烨之,吕宝经,朱向阳,黄国芳,杨谨文.生脉散对急性病毒性心肌炎患者血清脂质过氧化物的影响[J].中国中西医结合杂志,1996,16(3):142-145. |
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作者姓名: | 赵美华 荣烨之 吕宝经 朱向阳 黄国芳 杨谨文 |
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作者单位: | 上海第二医科大学附属新华医院心内科 |
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摘 要: | 本研究观察了生脉散对急性病毒性心肌炎患者血中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)等指标的影响。结果发现病毒性心肌炎患者中SOD、GSH-Px明显低于健康人(P<0.001),MDA明显高于健康人(P<0.001)。62例病毒性心肌炎患者分生脉散组和对照组,结果发现生脉散组(35例)患者血中SOD、GSH-Px较服药前明显增加(P<0.001);MDA显著降低(P<0.001)。对照组(27例)服药前、后SOD、GSH-Px及MDA无明显改变(P>0.05)。提示病毒性心肌炎患者心肌损伤与脂质过氧化反应有密切关系。生脉散具有抗氧自由基和抗脂质过氧化作用。能防治心肌损伤,是对病毒性心肌炎的有效治疗措施之一。
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关 键 词: | 病毒性 心肌炎 生脉散 抗脂质过氧化 抗氧自由基 |
Effect of Shengmaisan on Serum Lipid Peroxidation in Acute Viral Myocarditis |
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Authors: | ZHAO Mei-hua RONG Ye-zhi LU Bao-jing |
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Abstract: | The effect of Shengmaisan(SMS) on 62 acute viral myocarditis patients and its peroxidation damage was studied. The results revealed that the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in blood were decreased and the content of malondialdehyde(MDA) in plasma was increased in acute viral myocarditis patients in comparison with the healthy controls(P<0.001). 62 acute viral myocarditis patients were divided into two groups: SMS group and placebo group. After treatment, both SOD and GSH-Px activities were increased and the level of MDA decreased (P<0.001) in SMS group, while those in placebo group were not changed(P<0.05). The results suggested that the myocardial damage of viral myocarditis is closely related with lipid peroxidation SMS acts as an effective free radical scavenger and anti-lipid peroxidation drug. SMS could prevent the damage of myocardia and might be taken as one of the effective therapeutic methods in treatment of acute viral myocarditis. |
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Keywords: | viral myocarditis Shenginaisan anti-lipid peroxidation |
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