壮骨肾宝防治肾上腺皮质激素所致大鼠骨质疏松的实验研究

本研究采用３月龄ＳＤ雄性大鼠２４只，随机分为对照组（Ⅰ组）、激素组（Ⅱ组）和预防组（Ⅲ组）。Ⅱ组喂醋酸泼尼松２次／周；Ⅲ组除喂泼尼松外，还同时喂壮骨肾宝。３个月后对３组大鼠胫骨上段的骨片用图像分析仪进行和分析。激素组与对照组比较，由于骨吸收大于骨形成，出现骨小梁面积和数量减少，骨小梁之间的空隙增加。出现明显的骨质疏松症状。用壮骨肾宝预防的激素组，骨吸收率受到明显抑制，新骨形成增加，因而肾量明显增加

Experimental Study on Zhuanggu Shengbao in Preventing Hormone-Induced Osteoporosis of Rats

Twenty four male Sprague-Dawley rats at 3 months of age were divided randomly into 3 groups.Prednisone acetate was given to the group B twice per weeks, Zhuanggu Shengbao(ZGSB)was added to the group C besides prednisone,the group A was control.The histomorphometric parameters of bone slides of proximal tibia were measured and calculated with image pattern analyser after 3 months of medication.Results showed that in comparing with group A,in group B the area and number of trabecula decreased,the intertrabecular space increased due to the bone resorption exceeded the bone formation,and the symptoms of osteoporosis revealed obviously.However,in group C,the bone resorption rate was markedly inhibited, and the formation of new bone accelerated so that the bone mass increased significantly.These results indicated the ZGSB could prevent the osteoporosis induced by prednisone acetate.