靳三针治疗广泛性焦虑症的临床观察

目的观察靳三针治疗广泛性焦虑症的临床疗效。方法58例患者分别用抗焦虑药物（药物组,29例）和靳三针（针刺组,29例）治疗,疗程均为6周。采用HAMA、临床疗效总评量表和不良反应症状量表进行治疗前和治疗第2、4、6周末评定;用高效液相色谱-电化学法检测治疗前后血小板5-羟色胺（5-HT）、血浆皮质醇（CS）和促肾上腺皮质激素（ACTH）水平。结果（1）针刺组与药物组临床疗效相当,而不良反应针刺组却显著少于药物组（P〈0．05）。（2）两组治疗后血小板5-HT含量和血浆ACTH水平均比治疗前显著下降（P〈0．05）,但两组间比较差异无显著性;治疗前后两组血浆CS无显著变化。结论靳三针治疗焦虑症与常规西药治疗疗效相当．且不良反应少：并时血小板5-HT和血浆ACTH水平有调罄作用．

Clinical Study on "Jin's Three-needling" in Treatment of Generalized Anxiety Disorder

OBJECTIVE: To study the clinical effect of "Jin's three-needling" in the treatment of generalized anxiety disorder. METHODS: Fifty-eight patients with generalized anxiety were randomly assigned to two groups equally, the medication group treated with anti-anxiety drugs and the acupuncture group with "Jin's three-needling". The treatment course was 6 weeks. The clinical effects were evaluated with Hamilton anxiety scale (HAMA), clinical global impression (CGI), and treatment emergent symptom scale (TESS) before treatment and at the end of 2nd, 4th, 6th week of the treatment course. The concentration of 5-hydroxytryptamine (5-HT) in platelet, and plasma levels of corticosterone (CS) and adrenocorticotropic hormone (ACTH) were measured with high performance liquid chromatography-electrochemical detection (HPLC-ED) method before and after treatment. RESULTS: The clinical effects in the two groups were equivalent, while the adverse reaction found in the acupuncture group was less than that in the medication group (P < 0.05). The platelet concentration of 5-HT and plasma ACTH level decreased significantly in both groups after treatment with insignificant difference between the group (P < 0.05). The plasma CS level had no obvious change in the two groups after treatment as compared with that before treatment respectively. CONCLUSION: "Jin's three-needling" shows similar curative effect on generalized anxiety to routine Western medicine but with less adverse reaction, which may be realized through regulating the platelet 5-HT concentration and plasma ACTH level.