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抗震止痉胶囊对帕金森病作用机制的实验研究
引用本文:鲍远程,汪瀚,张波,陈怀珍,王晓阳,徐国存,王艳昕,杨兴涛.抗震止痉胶囊对帕金森病作用机制的实验研究[J].中国中西医结合杂志,2001,21(3):193-195.
作者姓名:鲍远程  汪瀚  张波  陈怀珍  王晓阳  徐国存  王艳昕  杨兴涛
作者单位:安徽中医学院第一附属医院神经内科合肥 230031
基金项目:安徽省教委高等学校自然科学基金资助课题(No.98JL086)
摘    要:目的:探讨抗震止痛胶囊对帕金森病(PD)大鼠作用机理。方法:采用6-羟基多巴胺微量注射损伤毁左侧黑质致密区复制帕金森病大鼠模型,将模型大鼠随机分为3组,分别用抗震止痉胶囊(中药组)、左旋多巴(西药组)和生理盐水(模型组)治疗30天,并检测各组大鼠治疗前后旋转行为,处死后测定各组左侧纹状体、黑质相关指标。结果:中药组大鼠旋转行为有一定改善作用(P<0.05);与模型组比较,纹状体多巴胺(DA)含量、DA/高香草酸(HVA)比值均增高(P<0.01),黑质谷胱甘肽过氧化物酶、超氧化物歧化酶、谷胱甘肽均显著升高(P<0.01),黑质谷胱甘肽过氧化物酶、超氧化物歧化酶、谷胱甘肽均显著升高(P<0.01),丙二醛降低(P<0.01)。西药组大鼠旋转行为明显改善(P<0.01)。结论:抗震止痛胶囊能部分改善PD大鼠旋转行为,提高纹状体DA含量及DA/HVA比例,其机制可能在于减轻自由基损害,减少DA分解代谢。

关 键 词:抗震止痛胶囊  帕金森病  旋转行为  多巴胺  高香草酸  脑黑质  氧化应激  中医药疗法
修稿时间:2000年8月9日

Preliminary Experimental Study on Therapeutic Mechanism of Kangzhen Zhijing Capsule in Treating Parkinson
Authors:BAO Yuan cheng  WANG Han  ZHANG Bo
Abstract:OBJECTIVE: To explore the therapeutic mechanism of Kangzhen Zhijing Capsule (KZZJC) on rats with Parkinson's disease (PD). METHODS: PD rat model was established by microinjection of 6-hydroxydopamine solution into left substantia nigra zona compacta (SNZC). Model rats were randomly divided into 3 groups and treated with KZZJC, levodopa and normal saline respectively for 30 days. The rotational behavior of rats before and after treatment was observed. Then rats were sacrificed and relevant indexes of left SNZC and striatum were examined. RESULTS: In rats treated with KZZJC, the rotational behavior was improved (P < 0.05), the levels of dopamine (DA) content and DA/homovanillic acid (HVA) ratio in striatum, and glutathione peroxidase, superoxide dismutase and glutathione in SNZC increased, but malondialdehyde in SNZC decreased, as compared with those in rats treated with normal saline, the difference was significant (P < 0.01 or P < 0.05). Rotational behavior in rats treated by levodopa was improved significantly (P < 0.01). CONCLUSION: KZZJC could partially improve the rotational behavior in PD model rats, increase DA content and DA/HVA ratio in striatum. The mechanism might be the reducing of free radical damage and DA catabolism.
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