金黄益胆颗粒对原发性胆管胆色素结石患者胆汁成分的影响

目的探讨金黄益胆颗粒对原发性胆管胆色素结石患者胆汁成分的影响。方法 66例原发性胆管胆色素结石患者随机分为对照组(未用中药)和服药组(服用金黄益胆颗粒)。留取术中、服药3、10、40天后经T管流出胆汁,检测其中总胆汁酸、总胆红素、直接胆红素、间接胆红素、单结合胆红素、糖蛋白、钙离子、β-葡萄糖醛酸酶、超氧阴离子自由基等成分的含量并进行对比。结果服药组3天后总胆汁酸上升,总胆红素及β-葡萄糖醛酸酶下降,与对照组同期比较差异有统计学意义(P<0.05);服药组10天及40天后总胆汁酸上升,总胆红素、间接胆红素、单结合胆红素、钙离子、β-葡萄糖醛酸酶、超氧阴离子自由基及糖蛋白下降,与对照组同期比较差异均有统计学意义(P<0.05,P<0.01);两组服药40天后各指标与本组术中比较总胆汁酸上升,总胆红素、间接胆红素、单结合胆红素、钙离子、β-葡萄糖醛酸酶、超氧阴离子自由基及糖蛋白下降,差异均有统计学意义(P<0.05,P<0.01)。结论金黄益胆颗粒可显著改善胆管结石的病理性胆汁成分,改善胆道内环境,对原发性胆管结石中的胆色素结石有一定的防治作用,且长期坚持服用效果更佳。

Effects of Jinhuang Yidan Granule on the Bile Compositions of Primary Bile Duct Pigment Calculus Patients

Objective To study the effects of Jinhuang Yidan Granule(JYD) on the bile compositions of primary bile duct pigment calculus patients.Methods Sixty-six patients with primary bile duct pigment calculus were randomly assigned to the control group(who took no Chinese medicine) and the JYD group(who took JYD).The bile from T-tube during the operation,3,10,and 40 days after medication were examined.The contents of bile acids,bilirubin(conjugated bilirubin,mono-conjugated bilirubin),glucoprotein,calcium ion,β-glucuronidase,superoxide radical anion,and other components were detected and compared.Results Three days after taking JYD,the total bile acids increased,the total bilirubin and β-glucuronidase decreased,showing statistical significance when compared with the control group(P<0.05).In the JYD group,the total bile acid increased,the total bilirubin,the conjugated bilirubin,the mono-conjugated bilirubin,glucoprotein,calcium ion,β-glucuronidase,superoxide radical anions decreased 10 and 40 days after medication,showing statistical significance when compared with the control group(P<0.05,P<0.01).The level of the total bile acid increased,the levels of the total bilirubin,the conjugated bilirubin,the mono-conjugated bilirubin,glucoprotein,calcium ion,β-glucuronidase,superoxide radical anions decreased after 40-day medication in the two groups,showing statistical significance when compared with the peri-operative indices of the same group(P<0.05,P<0.01).Conclusions JYD could significantly improve the pathologic bile compositions of the bile duct calculus,improve the environment of the biliary tract,showing certain preventive and therapeutic effects on bile pigment calculus of the primary bile duct calculus.Better effects may be obtained by long-term taking.