电针与益生菌合用黛力新对腹泻型肠易激综合征的疗效比较研究

目的探讨和比较电针与益生菌合用黛力新对腹泻型肠易激综合征(diarrhe atype of irritable bowel syndrome,D-IBS)的临床疗效。方法采用随机数字表法将64例伴有焦虑和(或)抑郁的D-IBS患者随机分成西药组(30例)和电针组(34例),西药组口服益生菌(地衣芽孢杆菌)和黛力新片,电针组予针刺后加电刺激,两组均治疗4周,并随访3个月。观察两组治疗前后消化道症状评分和汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分,以及3个月的随访复发情况。结果西药组总有效率为86.67%,电针组总有效率为88.24%,两组比较,差异无统计学意义(P>0.05)。两组治疗前后消化道症状评分、HAMA和HAMD量表评分组内比较差异均有统计学意义(P<0.05,P<0.01)。两组在排便次数评分和HAMA、HAMD量表评分改善方面比较,差异无统计学意义(P>0.05);腹痛、腹胀评分改善情况电针组优于西药组(P<0.01);粪便形状和黏液便评分改善西药组优于电针组(P<0.01);随访2个月内两组复发率比较,差异无统计学意义(P>0.05),随访3个月内电针组复发率明显低于西药组(P<0.05)。结论电针与益生菌合用黛力新均能有效治疗伴有焦虑和(或)抑郁的D-IBS,且在症状改善方面各有优势,但电针远期疗效较西药更好。

Comparison of the Therapeutic Effects of Electroacupuncture and Probiotics Combined with Deanxit in Treating Diarrhea-Predominant Irritable Bowel Syndrome

Objective To study and compare the therapeutic effects of electroacupuncture and probiotics combine Deanxit in treating diarrhea predominant irritable bowel syndrome(D-IBS).Methods Totally 64 D-IBS patients accompanied with anxiety and/or depression were randomly assigned to the Western medicine group(Group A)and the electroacupuncture(EA)group(Group B),30 patients in Group A and 34 patients in Group B.Patients in Group A took Bnfillus licheniformis and Deanxit,while those in Group B received EA.Four weeks consisted of one therapeutic course.Three-month follow-up was carried out.The scoring for the digestive tract symptoms,HAMA score,and HAMD score were evaluated before and after treatment.The recurrence in the 3-month follow-up was also observed.Results The total effect rate was 86.67% in Group A and 88.24% in Group B with no statistical difference between the two groups(P>0.05).There was statistical difference in the scoring for the digestive tract symptoms,HAMA score,and HAMD score(P<0.05,P<0.01).There was no statistical difference in the improvement of defecation frequency score,HAMA score,HAMD score between the two groups after treatment(P>0.05).Better effects on improving abdominal pain score and abdominal distention score was obtained in Group B(P<0.01),while better effects on improving the stool form score and mucus score were obtained in Group A(P<0.01).There was no statistical difference in the recurrence rate between the two groups within the two-month follow-up(P>0.05).The recurrence rate within the 3-month follow-up was obviously lower in Group B than in Group A(P<0.05).Conclusions EA and Western medicine(probiotics combined Deanxit)could effectively treat D-IBS patients accompanied with anxiety and/or depression.Both of them had different superiorities in improving symptoms.But EA had better long-term therapeutic effects.