中药配伍对血清阿魏酸临床生物利用度的影响 |
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引用本文: | 黄熙,任平,陈可冀,马晓昌,张莉,王骊丽.中药配伍对血清阿魏酸临床生物利用度的影响[J].中国中西医结合杂志,2001,21(1):7-9. |
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作者姓名: | 黄熙 任平 陈可冀 马晓昌 张莉 王骊丽 |
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作者单位: | 1. 第四军医大学西京医院中药临床药理研究室 西安 710032 2. 中国中医研究院西苑医院 |
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基金项目: | 国家自然科学基金资助项目(No.39870932,30070912),博士后基金96(4),高等学校骨干教师资助计划 |
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摘 要: | 目的:研究中药配伍对方剂吸收入人体内成分生物利用率的影响。方法:健康自愿者一次口服川芎汤(1g/kg),川芎芍药汽(2g/kg,两药之比为1:1),冠心Ⅱ叼汤(3g/kg,其中川芎为0.5g/kg),后,用建立的HPLC法测定吸收入循环血中的阿魏酸(FA)血药浓度-时间曲线,用梯形法计算血药浓度一时间曲线下面积(AUC),然后比较AUC值,结果:3组的血药浓度时间曲线均为双峰现象。与川芎汤的AUC(15734.88±7737.97)ng/(min.ml)比较,川芎配伍芍药后AUC(5717.92±6124.63)ng/(min.ml)值明显降低(P<0.01),而川芎配伍在冠心II号(川芎的剂量仅为川芎汤的50%)中的AUC(8072.00±4424.31)ng/(min.ml)相对不低,结论:冠心病Ⅱ号中药不影响FA的生物利用度,川芎芍药汽则影响明显。
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关 键 词: | 中药配伍 血药浓度 冠心Ⅱ号 生物利用度 阿魏酸 川芎芍药汤 |
修稿时间: | 2000年5月15日 |
Effect of Combination of Chinese Herbal Drugs on Clinical Bioavailability of Ferulic Acid in Serum |
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Authors: | HUANG Xi REN Ping CHEN Ke ji |
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Abstract: | OBJECTIVE: To observe the effect of combination of Chinese herbal drugs on bioavailability of Ligusticum walichii (LW) derived ferulic acid (FA) in serum. METHODS: Healthy volunteers were given LW decoction (1 g/kg), LW combined with Paeonia veitchii (PV, 1:1) decoction (2 g/kg) and Coronary Heart No. 2 (CH-II, 3 g/kg, containing LW 0.5 g/kg) once respectively. The serum FA concentration-time (c-t) curve was performed by HPLC using the method established by the authors, and the area under that curve (AUC) was calculated and compared. RESULTS: The FA c-t curve in the three groups was double peak curve. As compared with the AUC in subjects who were administered LW decoction, the AUC in those taken LW + PV decoction was lower (15734.88 +/- 7737.97) ng/(min.ml) vs (5717.92 +/- 6124.63) ng/(min.ml)], P < 0.05), while that in those taken CH-II was relatively higher (8072.00 +/- 4424.31) ng/(min.ml), P > 0.05)]. CONCLUSION: Combination of LW and PV could significantly lower the bioavailability of FA, but when LW was added in CH-II, the FA bioavailability was not affected. |
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Keywords: | combination of Chinese herbal drugs serum drug concentration area under serum drug concentration bioavailability |
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