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乳腺增生病中医证型与血管生成关系的临床观察
引用本文:宋爱莉,孙贻安,杨毅,叶林,李静蔚,刘晓菲.乳腺增生病中医证型与血管生成关系的临床观察[J].中国中西医结合杂志,2005,25(5):454-456.
作者姓名:宋爱莉  孙贻安  杨毅  叶林  李静蔚  刘晓菲
作者单位:1. 山东中医药大学附属医院乳腺外科,济南,250011
2. 山东中医药大学
摘    要:目的研究乳腺增生病不同中医证型与血管生成的关系,探讨乳腺增生病证型诊断的客观标准。方法140例乳腺增生病患者,按中医辨证类型分为3组,活检后观察病理分型、分级及血管内皮生长因子(vascular endothelial growth factor,VEGF)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)、微血管密度(microvascular density,MVD)的表达情况。结果140例乳腺增生病患者中,不同中医证型的病理分级及VEGF、bFGF、MVD表达差异有显著性(P<0.05);痰瘀互结型与肝郁气滞型、冲任失调型比较,非典型增生所占比例高,MVD计数多,VEGF与bFGF表达程度高(P<0.05)。结论乳腺增生病中医证型与血管活性及增生程度有相关性,病理特征及VEGF、bFGF、MVD表达可作为乳腺增生病中医证型研究、疗效判定的客观化指标。

关 键 词:乳腺增生病  中医证型  临床观察  生成关系  碱性成纤维细胞生长因子  血管内皮生长因子  factor  VEGF  bFGF  微血管密度  肝郁气滞型  痰瘀互结型  冲任失调型  非典型增生  MVD计数  病理特征及  客观化指标  血管生成  辨证类型  病理分型
修稿时间:2004年9月10日

Clinical Research on Relationship between Angiogensis and TCM Syndrome Type of Cyclomastopathy
Authors:SONG Ai-li  SUN Yi-an  YANG Yi
Abstract:ObjectiveTo study the relationship between angiogensis and TCM Syndrome type of cyclomastopathy (CMP) to investigate the objective standardization of TCM Syndrome diagnosis of the disease. MethodsOne hundred and forty patients with CMP were divided into three groups according to TCM syndrome typing. The pathological type, grade and expressions of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and microvascular density (MVD) in mammary biopsy were observed. ResultsThe expressions of VEGF, bFGF and MVD was different in CMP patients of different TCM types and pathological grades (P<0.05). The proportion of atypical proliferation, the count of MVD and the expression of VEGF and bFGF were higher in patients of phlegm and stasis type than those in Gan stagnation caused Qi-stagnation type and Chong and Ren meridians disorder type. ConclusionTCM Syndrome type of CMP patients is related with vascular activity and grade of angiogensis. The pathological characteristics of mammary tissue and expression of VEGF, bFGF and MVD can be regarded as the objective indexes of TCM typing and clinical efficacy evaluation for CMP.
Keywords:cyclomastopathy  TCM Syndrome typing  vascular endothelial growth factor  basic fibroblast growth factor  microvascular density  
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