白芍总甙联合甲氨蝶呤治疗类风湿关节炎临床分析

目的观察白芍总甙（TGP）联合甲氨蝶呤（MTX）治疗类风湿关节炎（RA）的疗效。方法260例RA患者分为治疗组180例和对照组80例,分别口服MTX＋TGP或MTX＋柳氮磺吡啶治疗,疗程均为24周。对两组治疗后的疗效及各项RA指标变化进行评估。结果治疗组和对照组在治疗4、8、12、24周总有效率分别为69%、81%、94%、98%和60%、85%、93%、94%,两组间比较差异无显著性（P〉0.05）。治疗后两组各项RA指标较治疗前均有不同程度的改善,治疗组较对照组改善更明显（P〈0.05）。结论TGP联合MTX能明显改善RA患者病情,起效快,且不良反应发生率低,患者依从性高。

Clinical Observation on Effect of Total Glucosides of Paeony Combined with Methotrexate on Rheumatoid Arthritis

Objective To observe the effect of total glucosides of paeony (TGP) combined with methotrexate (MTX) on rheumatoid arthritis (RA). Methods Two hundred and sixty patients were assigned to two groups, the treated group (180 cases) was orally administered with MTX plus TGP, and the control group (80 cases) with MTX plus sulfasalazine (SSZ). The therapeutic course for both groups was 24 weeks. The clinical effect and the indexes for RA were observed after treatment. Results The total effective rate at the 4th, 8th, 12th, 24th week of the treatment was 70%, 81%, 94%, 98% in the treated group, and 60%, 85%, 93%, 94% in the control, respectively, with insignificant difference found between the two groups (P>0.05). Various indexes of RA were markedly improved in both two groups after treatment but the improvement in the treated group was better than that in the control group (P<0.05). Conclusion TGP combined MTX treatment shows favorable effect on RA, showing a quicker initiation with less side-effect and higher compliance.