葛根素对冠心病患者纤溶功能及过氧化脂质的影响

目的：观察葛根素对冠心病患者血清超氧化物歧化酶（ＳＯＤ），过氧化脂质（ＬＰＯ），组织型纤维蛋白溶酶原激活物（ＴＰＡ）及组织型纤维蛋白溶酶原激活物抑制剂（ＰＡＩ－１）的影响。方法。将４８例患者分成葛根素治疗组和对照组，葛根素治疗组用葛根素注射液６００ｍｇ加入２５０ｍｌ液体中静滴注，每天１次，共１周，余治疗同对照组，用亚硝酸盐比色测定血清ＳＯＤ活力，放射免疫法血清ＳＯＤ含量，ＴＢＡ荧光显色法测定血清Ｌ

Effect of Puerarin on Fibrinolytic Activity and Lipid Peroxide in Patients with Coronary Heart Disease

To observe the effect of puerarin on superoxide dismutase (SOD), lipid peroxidation (LPO), tissue plasminogen (TPA) and plasminogen activator inhibitor (PAI 1) of coronary heart disease (CHD) patients. Methods: Forty eight patients were divided into two groups (treated group and control group). Treated group was given intravenously 600 mg puerarin, once daily for one week, also the same treatment as that of control was given. Nitrite colorimetric method, radioimmunoassay (RIA), TBA fluorescent development process and fibrinolysin specific colorbase substrate decomposition development process were used to determine SOD activity, SOD, LPO, TPA and PAI 1. Results: After the treatment with puerarin, SOD activity was increased, LPO reduced, while without any changes in the control group. There was insignificant changes of SOD between the treated and the control groups. TPA and PAI 1 were increased significantly in the treated group, but was insignificantly changed in the control group. Conclusion: Puerarin can increase the SOD activity, decrease LPO level and enhance the activity of fibrinolysis.