首页 | 本学科首页   官方微博 | 高级检索  
检索        

益髓生血颗粒治疗β-地中海贫血156例临床观察
引用本文:吴志奎,张新华,李敏,柴立民,刘咏梅,王荣新,蔡辉国,黄有文,易杰,王蕾,方素萍,陈智松,朱欲英,陈玉英,吕鑫霞.益髓生血颗粒治疗β-地中海贫血156例临床观察[J].中国中西医结合杂志,2006,26(4):352-354.
作者姓名:吴志奎  张新华  李敏  柴立民  刘咏梅  王荣新  蔡辉国  黄有文  易杰  王蕾  方素萍  陈智松  朱欲英  陈玉英  吕鑫霞
作者单位:1. 中国中医科学院广安门医院分子生物学研究室,北京,100053
2. 中国人民解放军第303医院
3. 中国医学科学院血液学研究所
4. 辽宁中医学院
基金项目:国家自然科学基金项目(No.30171199),国家自然科学基金重大研究计划(No.90409003)
摘    要:目的 研究益髓生血颗粒治疗β-地中海贫血临床效果及安全性。方法 在广西高发区用益髓生血颗粒治疗β-地中海贫血,疗程3个月,观察治疗前后临床症状、Hb、RBC、网织红细胞(Ret)、抗碱血红蛋白(HbF)水平变化并进行停药后3~6个月随访及不良反应的观察。结果治疗组患者自疗程第1个月起至3个月结束,Hb、RBC、Ret、HbF等各项血液学参数均有提高,与治疗前比较差异有显著性(P〈0.01);中医临床症状改善及动态观察与血液参数提高相一致,与治疗前比较差异有显著性(P〈0、01);156例中有效145例,无效11例,总有效率达92.9%。未见明显的不良反应。停药后随访结果显示,疗效维持时间3~4个月。结论 益髓生血颗粒治疗β-地中海贫血疗效显著,未见明显的不良反应。为中医药辨证治疗β-地中海贫血提供了一定的依据。

关 键 词:β-地中海贫血  益髓生血颗粒  中医证候
收稿时间:2005-08-05
修稿时间:2006-01-08

Clinical Observation on Effects of Yisui Shengxue Granule in Treating 156 Patients with β-thalassemia
Authors:WU Zhi-kui  ZHANG Xin-hu  LI Min
Abstract:OBJECTIVE: To study the clinical effect and security of Yisui Shengxue Granule (YSG) in treating beta-thalassemia. METHODS: One hundred and fifty-five patients with beta-thalassemia from high-incidence area in Guangxi Zhuang Autonomous Region were treated with YSG for 3 months. Clinical symptoms and levels of hemoglobin (Hb), red blood cell (RBC), reticulocyte (Ret) and hemoglobin F (HbF) were observed before and after treatment, and the adverse reaction occurred in the therapeutic course was observed as well. A 3-6 months follow-up study was performed after withdrawal of YSG. RESULTS: Levels of Hb, RBC, Ret and HbF obviously elevated, and clinical symptoms markedly improved in patients after treatment since the 1st month to the 3rd month (all P < 0.01). Dynamical observation showed that the improvement of symptoms was in accordance with the elevation of hemorrheological indexes. The treatment was effective in 145 patients and ineffective in 11, and the total effective rate being 92.9%, without any adverse reaction occurred. Follow-up study showed the therapeutic effect could be sustained for 3 to 4 months. CONCLUSION: YSG has evident effect on alpha-thalassemia without obvious adverse reaction, which provides a definite basis for treatment of beta-thalassemia with TCM.
Keywords:β-thalassemia  Yisui Shengxue Granule  TCM syndrome
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《中国中西医结合杂志》浏览原始摘要信息
点击此处可从《中国中西医结合杂志》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号