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糖微康胶囊治疗糖尿病肾病的临床观察
引用本文:林兰,倪青,高齐健,张润云,胡东鹏,刘喜明,苏诚炼,陈思兰,魏军平,李鸣镝.糖微康胶囊治疗糖尿病肾病的临床观察[J].中国中西医结合杂志,2000,20(11):811-814.
作者姓名:林兰  倪青  高齐健  张润云  胡东鹏  刘喜明  苏诚炼  陈思兰  魏军平  李鸣镝
作者单位:中国中医研究院广安门医院,北京
基金项目:国家“九五”攻关课题!(No .96 - 90 6 - 0 7)
摘    要:目的:观察糖微康胶囊治疗糖尿病肾病的疗效。方法:对确诊为糖尿病肾病的患者,采用随机方法分为两组,治疗组(78例)予糖微康胶囊,对照组(41例),予以阳性对照药开博通,观察治疗前后两组症状积分、尿系列微量蛋白(UAER、THP、β2-MG)、血糖、肾功能、血脂、血管紧张素I(AI)、血管紧张素Ⅱ(AⅡ)、心钠素(ANP);血栓素B2(TXB2)、6-酮-前列环素(6-keto-PGF1α)、内皮素1

关 键 词:糖微康胶囊  糖尿病肾病  肾功能  中医药疗法

Clinical Study on Tangweikang Capsule in Treating Diabetic Nephropathy
Authors:L Lin  Q Ni  Q Gao
Institution:Guang'anmen Hospital, China Academy of TCM, Beijing (100053).
Abstract:OBJECTIVE: To observe the effect of Tangweikang capsule (TWKC) in treating diabetic nephropathy (DN). METHODS: The 119 patients enrolled were divided into 2 groups, 78 patients in the TWKC group treated with TWKC and 41 patients in the control group treated with Captopril. The changes of symptom score, urinary microprotein series (urinary albumin excretion rate, Tamm-horsfall protein and beta 2-microglobulin), blood glucose, kidney function, blood lipid, angiotensin I (A I) and II (A II), atrial natriuretic polypeptide (ANP), thromboxane B2(TXB2), 6-keto-prostaglandin F1 alpha, endothelin 1 (ET-1) and collagen IV in patients after treatment were observed. RESULTS: The total effective rate in the TWKC group was 84.62%, which was superior to that in the control group (70.73%, P < 0.05). TWKC also showed better effects in improving clinical symptoms, lowering blood glucose, urinary microprotein series, blood lipid, A I, A II, ANP, ET-1 and collagen IV, ameliorating kidney function, and adjusting dynamic equilibrium of thromboxane-prostacyclin system, as compared with the control group (P < 0.05 or P < 0.01). CONCLUSION: TWKC could lower the levels of blood glucose and lipid, improve the glucose and lipid metabolism, regulate the microcirculation, ameliorate the degree of kidney damage, therefore, it showed a better effect in treating diabetic nephropathy.
Keywords:Tangweikang capsule  diabetic nephropathy  kidney function?
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