类风湿性关节炎两种不同证型与三种可溶性细胞因子受体？…

目的：探讨痹证中类风湿性关节炎（ＲＡ）的两种证型（寒湿阻络证和湿热阻络证）与３种可溶性细胞因子受体，即可溶性白细胞介素２、６受体，可溶性肿瘤坏死因子受体之间的关系。方法：用ＥＬＩＳＡ法测定两证型患者血清中３种ｓＣＫＲ。结果：ＲＡ患者中３种ｓＣＫＲ均显著高于健康人，经治疗后均显著下降；寒湿阻络证ｓＩＬ－２Ｒ显著高于湿热阻络证，而ｓＴＮＦＲ１显著你芋湿热阻络证，ｓＩＬ－６Ｒ则两证型未见明显差异。结论：

Study on relationship between two different syndromes and three soluble cytokine receptors in patients with rheumatoid arthritis]

OBJECTIVE: To study the relationship between two different Syndromes (Cold-Damp Syndrome and Damp-Heat Syndrome) and three soluble cytokine receptors (sCKR, soluble interleukin-2 receptor, sIL-2R, soluble interleukin-6 receptor, sIL-6R, soluble tumor necrosis factor receptor 1, sTNFR1) in rheumatoid arthritis (RA). METHODS: The serum levels of three soluble receptors were measured by ELISA in patients with RA. RESULTS: The serum levels of 3 sCKR were significantly elevated in RA patients compared to healthy controls and obviously lowered after treatment (P < 0.01). The level of sIL-2R was significantly higher in Cold-Damp Syndrome than that in Damp-Heat Syndrome (P < 0.01), but serum sTNFR1 was significantly higher in Damp-Heat Syndrome than that in Cold-Damp Syndrome, there was no obvious difference between sIL-6R of two Syndromes. CONCLUSION: The high serum sIL-2R and low sTNFR1 might be a criterion of Cold-Damp Syndrome, but the high sTNFR1 and low sIL-2R might be a criterion of Damp-Heat Syndrome, these criteria reflected some states of different functions in immune system in patients with RA.