定心方对家兔心肌缺血及再灌注损伤的保护作用和抗心？…

目的：研究定心方（ＤＸＲ）抗兔心肌缺血及再灌注损伤和抗心律失常作用，方法：兔冠状动脉双重结扎造成心肌梗塞，观察各组心律失常情况并检测血浆超氧化物歧化酶（ＳＯＤ），ｃＡＭＰ，去甲肾上腺素（ＮＥ），多巴胺（ＤＡ），５－羟色胺（５－ＨＴ），观察心肌超微结构。结果：ＤＸＲ对兔心肌梗塞后心律失常有拮抗作用，其中ＤＸＲ大剂量组与对照组比较有显著性差异（Ｐ〈０．０１）；对缺血再灌注心律失常也有拮抗作用，ＤＸＲ大

Effect of dingxin recipe on arrhythmia and injury induced by ischemia and reperfusion in rabbits]

OBJECTIVE: To investigate the protective effect of Dingxin Recipe (DXR) on arrhythmia and injury induced by ischemia and reperfusion. METHODS: Rabbits were randomly divided into four groups and administered orally with DXR of high dose, low dose, propanolol and distilled water. Two-step coronary artery ligature was used to form ischemia and reperfusion model. Superoxide dismutase (SOD), cyclic adenosine monophosphate (cAMP), norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), myocyte ultrastructural injury and occurrence of arrhythmia were investigated. RESULTS: DXR could obviously antagonize arrhythmia induced by myocardial infarction or ischemia and reperfusion in rabbits. Compared with the control group, DXR of high and low doses could improve the changes in ST-T. In rabbits treated with DXR, the levels of SOD were elevated while cAMP, NE, DA, 5-HT and the whole blood viscosity were lowered. CONCLUSIONS: DXR could obviously antagonize arrhythmia and injury induced by ischemia and reperfusion, DXR may clear oxygen free radical, regulate the second messenger, inhibit sympathetic nerve system, improve local circulation, protect mitochondria and prevent the activation of lysosome and safeguard the cardiac myocyte to be free from injury.