2型糖尿病血瘀证患者血小板CD62p、CD63测定意义探讨

目的；研究２型糖尿病患者血小板活化与血瘀证的关系及其影响因素。方法：用单克隆抗体作分子探针，经流式细胞术测定了３０例２型糖尿病血瘀证患者，２７例２型糖尿病非血瘀证患者及２０名健康者的血小板膜糖蛋白ＣＤ６２ｐＣＤ６３表达。结果：２型糖尿病血瘀证组ＣＤ６２ｐ，ＣＤ６３显著高于非血瘀证组及对照组，血瘀证组ＣＤ６２ｐ与ＣＤ６３呈正相关，ＣＤ６２ｐ与糖化血红蛋白，低密度脂蛋白胆固醇呈正相关。

Significance of Platelet CD62p , CD63 Assessment in Type 2 Diabetes Mellitus Patients with Blood Stasis

To study the relationship between blood stasis and platelet activation and the influential factors on the latter in type 2 diabetes mellitus (DM) patients. Methods: Platelet CD 62p , CD 63 expressions were determined in 30 patients of type 2 DM with blood stasis, 27 patients of type 2 DM without blood stasis and 20 normal controls by flow cytometry. Results: CD 62p , CD 63 levels were significantly higher in type 2 DM with blood stasis group than that without blood stasis group and in normal controls. CD 62p was positively correlated with CD 63 , while positive correlation existed between HbA lc, LDL C and CD 62p in DM patients with blood stasis. Conclusion: The increased level of platelet activation was the primary molecular basis in type 2 DM. It was important to perform the Syndrome Differentiation of blood stasis and treatment of activating blood circulation to remove blood stasis in type 2 DM.