炎症因子与十二指肠溃疡寒热辨证的关系

目的：探讨炎症因子与十二指肠溃疡的寒热辨证关系。方法；对４８例址二指肠溃疡２进行中医寒热辨证，胃镜下作胃窦部活检，测定胃粘膜组织白介素８（ＩＬ－８）及白介素６（ＩＬ－６），并测定肿瘤坏死因子（ＴＮＦ）、丙二醛（ＭＤＡ）、髓过氧化物酶（ＭＰＯ）、然后进行对比分析，并与１０例正常胃粘膜活检标本作比较。结果：热证组胃粘膜ＩＬ－８、ＴＮＦ、ＭＰＯ及ＭＤＡ较寒证组增多；ＩＬ－６与寒热辨证无明显关系。结论：炎

Relationship of Cytokines and Cold Heat Syndrome Differentiation in Patients of Duodenal Ulcer

Objective: To explore the relationship of cytokines and Cold Heat Syndrome in patients of duodenal ulcer. Methods: Cold Heat Syndrome Differentiation was done in 48 patients of duodenal ulcer, and the levels of interleukin 8 (IL 8), interleukin 6 (IL 6), tumor necrosis factor (TNF), malonyldialdehyde (MDA), marrow peroxidase (MPO) in gastric mucosa biopsy were measured and compared with those of 10 normal subjects. Results: Levels of IL 8, TNF, MPO and MDA in Heat Syndrome were higher than those in Cold Syndrome (P<0 05), while IL 6 level showed no significant relationship with Cold Heat Syndrome. Conclusion: Cytokines IL 8, TNF, MPO and MDA are correlated with Cold Heat Syndrome in duodenal ulcer patients and which might be one of the molecular mechanisms of Cold Heat Syndrome Differentiation.