益肾生血片治疗再生障碍性贫血的实验研究

目的：探讨益明生血片治疗再生障碍性贫血（再障）的作用机理。方法：观察了该药对小鼠造血功能，免疫功能，抗感染力和抵抗力的影响。结果：益肾生血片对马利兰引起的造血损伤小鼠多能造血干细胞（ＣＦＵ－Ｓ）、粒素祖细胞（ＣＦＵ－Ｃ）和红系祖细胞（ＣＦＵ－Ｅ）的微量的恢复有明显促进作用；对正常小鼠腹腔巨噬细胞吞噬功能有明显促进作用；可明显降低接种金黄色葡萄球菌小鼠的死亡率；在常压缺氧时，可使小鼠耐缺氧能力明显提

Experimental Study on Effect of Yishen Shengxue Tablet in Treating Aplastic Anemia

Objective: To study the mechanism of Yishen Shengxue Tablet (YSSXT) in treating aplastic anemia. Methods: Observing the effect of YSSXT on hematopoietic, immunologic, anti infection and body resistance of model mice of aplastic anemia. Results: YSSXT had marked effect of promotion on recovering myleran injury induced reduction of colony forming unit spleen (CFU S), colony forming unit culture (CFU C), colony forming unit erythrocyte (CFU E), markedly promoting the peritoneal macrophage phagocytosis of normal mice, also markedly lower the mortality of Staphylococcus aureus inoculated mice, and elevate the anoxia resistant ability under normal pressure of anoxic mice, prolonging their survival time. Conclusion: Using YSSXT to treat aplastic anemia that the effectiveness might be realized through promoting the proliferation of hematopoietic stem cells of bone marrow, enhancing the non specific immunity, and the anti infectionn as well as body resistance.