| 大蒜精油抑制白细胞介素—1α诱导的单核细胞—内皮细胞粘？… |
| |
| 引用本文： | 葛璐璐 张薇. 大蒜精油抑制白细胞介素—1α诱导的单核细胞—内皮细胞粘？…[J]. 中国中西医结合杂志, 1999, 19(3): 152-154 |
| |
| 作者姓名： | 葛璐璐 张薇 |
| |
| 作者单位： | 第一军医大学组织胚胎学教研室 |
| |
| 摘 要： | 目的：观察大蒜精油（ＥＧＯ）对白细胞介素－１α（ＩＬ－１α）诱导的人脐静脉内皮细胞（ＨＵＶＥＣ）上血管细胞粘附分子－１（ＶＣＡＭ－１）表达及单核细胞粘附率的影响。
|
| 关 键 词： | 大蒜精油 内皮细胞 VCAM－1 IL－1α 单核细胞 |
Study on effect and mechanism of essential garlic oil in inhibiting monocyte-vascular endothelial cell adhesion induced by interleukin-1 alpha] |
| |
| L Ge,W Zhang,Y Dai. Study on effect and mechanism of essential garlic oil in inhibiting monocyte-vascular endothelial cell adhesion induced by interleukin-1 alpha][J]. Chinese journal of integrated traditional and Western medicine, 1999, 19(3): 152-154 |
| |
| Authors: | L Ge W Zhang Y Dai |
| |
| Affiliation: | First Military Medical University, Guangzhou (510515). |
| |
| Abstract: | OBJECTIVE: To observe the effects of essential garlic oil (EGO) on vascular cell adhesive molecule-1 (VCAM-1) expression of endothelial cell and monocyte adhesion induced by interleukin-1 alpha (IL-1 alpha). METHODS: Human umbilical vein endothelial cells (HUVEC) were isolated by pancreatin digestion method and co-cultured with U937 monocyte and IL-1 alpha or EGO + IL-1 alpha respectively. The adhesion rate of monocyte to endothelial cell was measured and mean fluorescent intensity of immuno-stained of VCAM-1 was determined by ACAS 570. RESULTS: EGO showed significant inhibition on VCAM-1 expression induced by IL-1 alpha either in simple culture with HUVEC or in co-culture with HUVEC + U937, and could obviously down regulate the monocyte-endothelial cell adhesion under effect of IL-1 alpha. CONCLUSION: EGO has the effect of antagonizing against adhesion of monocyte and vascular endothelial cell, it may be due to the inhibition of EGO on adhesive molecular expression on endothelial cell. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
