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雷公藤制剂副作用的临床观察
引用本文:周嘉陵,朱琦,杨晓凌,张芳.雷公藤制剂副作用的临床观察[J].中国中西医结合杂志,1999,19(2):77-79.
作者姓名:周嘉陵  朱琦  杨晓凌  张芳
作者单位:上海光华中西医结合医院
摘    要:目的;观察雷公藤制剂的副作用。方法:应用雷公藤制剂治疗类风湿关节炎患者271例,并观察其副作用发生情况。结果;雷公藤叶提取物雷诺酯片比雷公藤根提限物雷公藤片对生殖系统影响小。雷公藤根蕊提取物雷公藤多甙片在治疗RA中,每日60mg大剂量比每日30mg小剂量副作用发生率高。〈50岁女性患者主要副作用以月经失调为主;〉50岁患者要注意对肾脏的影响。在长期应用中,雷公藤多甙片的副作用主要发生在前10年。雷

关 键 词:雷公藤制剂  类风湿性关节炎  药物副作用

Clinical Observation of Side Effects of Tripterygium Preparation
Authors:Zhou Jialing  Zhu Qi  Yang Xiaoling  Guanghua Hospital of Integrated Traditional Chinese and Western Medicine  Shanghai
Abstract:Objective: To observe the side effects of Tripterygium preparation (TP) in the course of treatment. Methods: Two hundred and seventy one cases of patients with rheumatoid arthritis (RA) were treated using various TP to observe the occurrence of adverse reaction. Results: The influence on reproductive system with TP extracted from the leaf ester tab were less than that from the root (TP tab and TP multiglycoside tab, TPMG). In group of TPMG the rate of side effect of 60 mg daily dosage was more than 30 mg daily (P<0 01). The main influence on digestive tract and irregular manstruation was before age of 50 years and on renal function was after age of 50 years. Those adverse reactions mainly occur within first ten years in long therapy period. The side effects of TPMG produced in the Dampness Heat type of RA were lower than Yin Deficiency of Liver and Kidney type of RA (P<0 05). Conclusion: TP ester tab is available for young woman and TPMG tab is suitable for the Dampness Heat type of RA with lower dosis maintainance therapy.
Keywords:Tripterygium  rheumatoid arthritis  side effect
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