氧化苦参碱治疗慢性乙型病毒性肝炎疗效及其与HBV负荷的关系探讨 |
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引用本文: | 陈燕熙,茅佰元,江建华,施建华,李继强.氧化苦参碱治疗慢性乙型病毒性肝炎疗效及其与HBV负荷的关系探讨[J].中国中西医结合杂志,2002,22(5):335-336. |
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作者姓名: | 陈燕熙 茅佰元 江建华 施建华 李继强 |
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作者单位: | 1. 江苏省海门市卫生防疫站,江苏,226100 2. 上海第二医科大学附属仁济医院,上海市消化疾病研究所 |
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摘 要: | 目的:研究氧化苦参碱治疗慢性乙型病毒性肝炎疗效及其与HBV负荷的关系。方法:44例慢性乙型肝炎患者,随机分为治疗组(给予氧化苦参碱和一般护肝药物)23例,对照组(仅给予一般护肝药物)21例。以聚合酶链反应(PCR)法一量测定血清HBV水平,分析不同疗效与不同血清HBV负荷的关系。结果:氧化苦参碱肌肉注射慢性乙型肝炎3个月(0.4g/d),HBVDNA及HBeAg转阴率均为43.47%,明显优于对照组(P<0.05)。治疗后HBVDNA定量水平从10^6.83±1.27copy/ml降至10^3.35±3.08copy/ml,治疗后HBeAg转阴的患者,其治疗前血清HBVDNA定量水平(10^6.30±1.42copy/ml),明显低于未转阴者(10^7.23±1.23copy/ml)。结论:氧化苦参碱治疗慢性乙型肝炎有效,治疗前血清HBVDNA水平较低者疗效较好。
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关 键 词: | 氧化苦参碱 慢性乙型肝炎 乙型肝炎病毒 聚合酶链反应 治疗 疗效 |
修稿时间: | 2001年6月11日 |
Relationship between Serum Load of HBV-DNA and Therapeutic Effect of Oxymatrine in Patients with Chronic Hepatitis B |
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Authors: | CHEN Yan xi MAO Bai yuan JIANG Jian hua |
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Abstract: | OBJECTIVE: To study the relationship between serum load level of HBV-DNA and therapeutic effect of oxymatrine in patients with chronic hepatitis B. METHODS: Forty-four patients of chronic hepatitis B were divided into two groups, the treated group was treated with oxymatrine 0.4 g/d by intramuscular injection for 3 months, the control group was treated with some liver protecting agents to estimate the therapeutic effect. The serum level of HBV-DNA was determined by quantitative polymerase chain reaction (PCR) before and after treatment. RESULTS: The seroconversion rate of HBV-DNA and HBeAg in the treated group was 43.47% and 43.47% respectively, which was obviously better than those in the control group respectively (P < 0.05), the quantity of HBV-DNA decreased after treatment from 10(6.83 +/- 1.27) copy/ml to 10(3.35 +/- 3.08) copy/ml. Among them, in patient with HBeAg negative conversion, the pretreatment quantity of HBV-DNA was 10(6.30 +/- 1.42) copy/ml, while in those with no HBeAg negative conversion, it was 10(7.23 +/- 1.23) copy/ml, the difference was significant. CONCLUSION: Oxymatrine is effective in treating chronic hepatitis B. The therapeutic effect is better for patients with lower quantity of serum HBV-DNA. |
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Keywords: | oxymatrine chronic hepatitis B hepatitis B virus polymerase chain reaction |
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