复方丹参注射液治疗中重度新生儿缺氧缺血性脑病的临床观察

目的：观察新生儿缺氧缺血性脑病（HIE）时血液与脑脊液中内皮素（ET－1）、一氧化氮（NO）、肌酸磷酸激酶脑型同功酶（CK－BB）的含量变化，探讨复方丹参注射液治疗中重度新生儿HIE的疗效。方法：将60例中重度HIE患儿随机分成治疗组和对照组，治疗组在常规治疗的基础上加用复方丹参注射液，分别于急性期及恢复期检测血液与脑脊液中ET－1、NO、CK－BB的含量，观察两组临床疗效的差异。结果：治疗组显效率及有效率分别为80．0％及93．3％，对照组显效率及有效率分别为66．7％及83．3％，两组比较，差异均有显著性（χ^2=6.23,P<0.05;χ^2=4.35,P<0.05)。两组血浆与脑脊液中ET－1、NO及CK－BB水平随着疾病的恢复均下降，且治疗组下降幅度较大。结论：ET－1、CK－BB参与了HIE的病理过程，复方丹参注射液治疗中重度新生儿HIE有显著效果。

Clinical Observation of Compound Salvia Injection in Treating Mid-Severe Infantile Hypoxic-Ischemic Encephalopathy

Objective: To observe the changes of endothelin 1 (ET 1), nitrogen oxide (NO) and creatine phosphokinase BB isozyme (CK BB) in blood and cerebrospinal fluid (CSF) in patients of infantile hypoxic ishemic encephalopathy (HIE), and explore the efficacy of compound Salvia injection (CSI) in treating mid severe HIE. Methods: Sixty mid severe infantile HIE patients were divided randomly into the treated and the control group. To the treated group CSI was added on the basis of conventional treatment, and to the control group the conventional treatment was given alone. The blood and CSF content of ET 1, NO and CK BB at acute and convalescent stage in the two groups were determined and the therapeutic effects were compared between the two groups. Results: The markedly effective rate and effective rate of the treated group was 80 0% and 93 3% respectively, while that of the control group was 66 7% and 83 3% respectively, the therapeutic effect in the treated group were obviously superior to that in the control group, the difference was significant (P<0 05). Conclusion: ET 1, NO and CK BB participated the pathological process of HIE. CSI was markedly effective in treating mid and severe HIE infants.