| 肾衰宁对体外培养的肾小球系膜细胞增殖及其分泌细胞因 … |
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| 引用本文： | 刘铜华,叶传蕙.肾衰宁对体外培养的肾小球系膜细胞增殖及其分泌细胞因 …[J].中国中西医结合杂志,1999,19(5):299-301. |
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| 作者姓名： | 刘铜华 叶传蕙 |
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| 作者单位： | 北京中医药大学(刘铜华)，成都中医药大学附属医院(叶传蕙) |
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| 摘 要： | 目的：探讨肾衰宁对系膜细胞增主其分泌细胞因子白细胞介素－１（ＩＬ－１）的影响。方法：采用血清药理学方法，提取动物的含药血清作用于体外培养的人细胞（ＨＭＣ）体系，观察具有益气固本、化瘀泻浊作用的中药肾衰宁对ＨＭＣ增殖及其分泌细胞因子ＩＬ－２的影响。结果：肾衰宁具有抑制ＨＭＣ增殖及其分泌细胞因子ＩＬ－１的作用，该抑制作用具有一定的量效关系。结论：ＨＭＣ是肾衰宁发挥治疗作用的重要靶细胞，这可能是该方防治
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| 关 键 词： | 肾衰宁 人系膜细胞 肾功能衰竭 IL－1 药理 |
Effect of Shenshuaining on Proliferation and Autocrine Interleukin 1 Secretion of Human Mesangial Cells |
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| Authors: | Liu Tonghua Ye Chuanhui Beijing University of Traditional Chinese Medicine and Pharmacology Beijing |
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| Abstract: | Objective: To explore the effect of Shenshuaining (SSN), on the proliferation of human mesangial cells (HMC) and the autocrine secretion of interleukin 1 (IL 1). Methods: SSN, a preparation of Chinese herbal drug having actions of Qi supplementing, origin consolidation, blood stasis resolving and turbid substance removing, medicated serum of animal was extracted by pharmacologic method and its effect on proliferation and autocrine IL 1 secretion of HMC was observed. Results: SSN could inhibit the proliferation and IL 1 autocrine secretion of HMC, and the inhibition was dose dependent. Conclusion: Mesangial cell is the important target cell for action of SSN, the inhibition on HMC may be one of the mechanisms of SSN in prevention and treatment of chronic renal failure. |
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| Keywords: | Shenshuaining human mesangial cell interleukin 1 chronic renal failure |
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