银杏叶提取物对早期糖尿病肾病患者细胞间黏附分子-1和血管细胞黏附分子-1水平的影响

目的 探讨银杏叶提取物对早期糖尿病肾病患者血清可溶性细胞间黏附分子-1（sICAM-1）和可溶性血管细胞黏附分子-1（sVCAM-1）水平的影响。方法 63例早期糖尿病肾病患者随机分为两组，对照组（29例）采用糖尿病常规西医治疗，治疗组（34例）在常规治疗基础上加用银杏叶片，疗程均为2个月，采用酶联免疫吸附法（ELISA）测定两组患者治疗前后血清sICAM-1、sVCAM-1水平，同时观察尿白蛋白排泄率（UAER）、空腹血糖（FPG）、血肌酐（SCr）、血脂等指标的变化：结果与治疗前比较，两组患者治疗后血清sICAM-1、sVCAM-1水平下降（P〈0．05或P〈0．01），治疗组下降更为明显（P〈0．01）。治疗组治疗后UAER明显降低，SCr、血脂水平改善（P〈0．05或P〈0．01）：结论 银杏叶提取物可通过降低早期糖尿病肾病患者血清sICAM-1、sVCAM-1水平而延缓糖尿病肾病的发展。

Effect of Extract of Gingko biloba on Soluble Intercellular Adhesion Molecule-1 and Soluble Vascular Cell Adhesion Molecule-1 in Patients with Early Diabetic Nephropathy

Objective To investigate the effect of extract of Gingko biloba(EGb) on soluble intercellular cell adhesion molecule-1(sICAM-1) and soluble vascular cell adhesion molecule-1(sVCAM-1) in patients with early diabetic nephropathy(DN).Methods Sixty-three patients with DN in early stage were randomly assigned to the control group(29 cases) and the treatment group(34 cases).Both groups were treated by routine treatment,and with EGb given to the treatment group additionally.The treatment course was 2 months.Serum sICAM-1 and sVCAM-1 were determined with ELISA before and after treatment,and urinary albumin excretion rate(UAER),fasting plasma glucose(FPG),serum creatinine(SCr) and blood lipids,etc.were examined as well.Results The levels of serum sICAM-1 and sVCAM-1 were significantly lower in both groups after treatment than those before treatment(P<0.05 or P<0.01),and the decrement in the treatment group was more significant than that in the control group(P<0.01).And the levels of UAER,SCr and blood lipids decreased in the treatment group after treatment(P<0.05 or P<0.01).Conclusion EGb could retard the development of early DN through decreasing the levels of serum sICAM-1 and sVCAM-1.