沙参麦冬汤对甲状腺癌术后免疫功能的影响:随机对照研究

目的观察沙参麦冬汤对甲状腺癌患者术后免疫功能的影响。方法选择甲状腺癌术后患者77例,采用随机数字表法分为观察组(41例)和对照组(36例)。对照组采用左甲状腺素钠片+安慰剂治疗;观察组采用左甲状腺素钠片+沙参麦冬汤治疗。疗程为6周。评价两组临床疗效改善率;采用癌症患者生活质量指数(QLI,包括:活动能力、日常生活、健康感受、外界支持和人生观)评估量表评价生活质量;比较两组自然杀伤细胞(NK)活性、T淋巴细胞亚群及免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平。结果观察组总改善率77.78%(28/36)]显著高于对照组53.13%(17/32),P<0.05]。与治疗前比较,观察组和对照组治疗后活动能力、日常生活、健康感受、人生观评分和总分,NK细胞百分比,CD3^+、CD4^+T百分比和CD4^+/CD8^+比值,IgM、IgG水平升高(P<0.05,P<0.01),CD8^+T百分比降低(P<0.05,P<0.01)。与对照组比较,观察组治疗后活动能力、日常生活、健康感受、人生观评分和总分,NK细胞百分比,CD3^+、CD4^+T百分比和CD4^+/CD8^+比值,IgM、IgG水平升高(P<0.05,P<0.01),CD8^+T百分比降低(P<0.01)。结论沙参麦冬汤可提高甲状腺癌术后临床疗效,改善患者生活质量,增强患者免疫功能。

Effect of Shashen Maidong Decoction on Immune Function in Patients after Thyroid Carcinoma Operation: A Randomized Controlled Trial

Objective To observe the effect of Shashen Maidong Decoction on immune function in patients after thyroid carcinoma operation.Methods Seventy-seven patients after thyroid carcinoma operation were randomly assigned into observation group(41 cases)and control group(36 cases)by random number table method.The observation group was treated with levothyroxine sodium tablet and Shashen Maidong Decoction,and the control group was treated with levothyroxine sodium tablet and placebo.The treatment courses for all were 6 weeks.The improvement rate of clinical efficacy was evaluated in both groups.Quality of life(activity,daily life,health,support,and outlook on life)was assessed by Quality of Life Index(QLI).Natural killer cell(NK)activity,T lymphocyte subpopulations and immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)level were compared in both groups.ResultsThe total improvement rate77.78%(28/36)]in observation group was significantly higher than that in control group53.13%(17/32),P<0.05].Compared with those before treatment,activity,daily life,health,outlook on life and total score,the percentage of NK cells,the percentages of CD3^+,CD4^+T cells and CD4^+/CD8^+ratio and IgM,IgG level were increased(P<0.05,P<0.01),and the percentages of CD8^+T cells were reduced(P<0.05,P<0.01)in both groups.At the end of treatment,activity,daily life,health,outlook on life and total score,the percentages of NK cells,the percentages of CD3^+,CD4^+T cells and CD4^+/CD8^+ratio and IgM,IgG level in observation group were significantly increased(P<0.05,P<0.01),and the percentages of CD8^+T cells in observation group were significantly reduced(P<0.01)than those in control group.Conclusion Shashen Maidong Decoction can improve clinical efficacy and quality of life,and enhance immune function in patients after thyroid carcinoma operation.