乙型肝炎病毒BCP联合点突变与中医证型的关系

目的 观察乙型肝炎病毒（hepatitis Bvirus，HBV）基本C区启动子（basal core promoter，BCP）联合点突变与中医证型的关系。方法 收集未经拉米夫定及干扰素治疗的HBV DNA阳性慢性乙型肝炎患者102例，分为湿热中阻型、肝郁脾虚型、肝肾阴虚型、脾肾阳虚型和瘀血阻络型，分别检测血清HBV DNA、肝脏生化指标及BCPnt 1762A-T和nt1764G-A联合点突变。结果 实证组的变异株检出率明显高于虚证组，其中湿热中阻型患者变异株的检出率最高。结论 实证者可能较易发生BCP联合点突变，其中湿热中阻型患者可能更为显著。

Relationship between Basal Core Promoter Combined Point Mutation of Hepatitis B Virus and TCM Syndrome Type

ObjectiveTo investigate the relationship between basal core promoter (BCP) combined point mutation of hepatitis B virus (HBV) and TCM syndrome type. MethodsOne hundred and two patients with chronic hepatitis with positive HBV DNA and hadn't ever been treated by Lamivudine and interferon were differentiated according TCM syndrome differentiation into 5 types, two excess types (damp-heat blocking Zhong-jiao type and blood stasis blocking collaterals type) and three deficiency types, Gan-stagnation with Pi-dificiency type, Gan-Shen Yin-deficiency type and Pi-Shen Yang-deficiency type. The serum HBV DNA, hepatic biochemical indexes, and the mutation of BCPnt 1762A-T and nt1764G-A combined point were determined, respectively. ResultsThe variant strain positive rate detected in the excess type was significantly higher than that in the deficiency type, the highest rate appeared in patients of damp-heat blocking Zhong-jiao type. ConclusionBCP combined point mutation may be liable to happen in patients of TCM excess type, especially in patients of damp-heat blocking Zhong-jiao type.