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血府逐瘀丸对患者颈动脉粥样硬化的影响
引用本文:李艳梅,陈可冀,张学文,王敦礼,史载祥,张铁忠.血府逐瘀丸对患者颈动脉粥样硬化的影响[J].中国中西医结合杂志,1997(3):152-154.
作者姓名:李艳梅  陈可冀  张学文  王敦礼  史载祥  张铁忠
作者单位:中国中医研究院西苑医院,北京中日友好医院,天津中医学院第一附属医院
摘    要:目的:观察血府逐瘀丸对患者颈动脉粥样硬化的影响。方法:采用彩色多普勒颈动脉超声法,对中药复方血府逐瘀丸治疗10例颈动脉粥样硬化患者的疗效进行了观察。结果:血府逐瘀丸治疗的患者,其颈总动脉内膜-中膜厚度有所降低,治疗前后差值为0.13±0.03mm(P<0.001),对颈动脉粥样硬化斑块的厚度和面积分别降低0.11±0.05cm和0.09±0.04cm2(P均<0.05);而阿斯匹林治疗的对照组患者其颈总动脉内膜-中膜厚度、动脉粥样硬化斑块的厚度和面积均无明显变化(P均>0.05)。结论:血府逐瘀丸对颈动脉粥样硬化病变有一定的治疗作用。

关 键 词:颈动脉粥样硬化,血府逐瘀丸,彩色多普勒超声

Effect of Xuefuzhuyu Pill on Patients with Carotid Atherosclerosis by Colour Doppler Ultrasonography
Authors:LI Yan-mei  CHEN Ke-ji  ZHANG Xue-wen  
Abstract:To observe the effect of Xuefuzhuyu Pill(XFZYP) on carotid atherosclerosis. Methods:The patients were randomly divided into XFZYP group and aspirin control group. The status of the carotid plaque vessel wall and bind flow were observed by colored Doppler ultrasonography. Results: (1 )Plaque of 6 cases regressed, of 6 cases unchanged, of 1 case progressed after treatment of XFZYP. The area of plaques between baseline and after treatment decreased 0. 11 ± 0. 05cm and that of thickness reduced for 0. 09± 0. 04cm2 (P<0. 05)in XFZYP group. While plaque of 3 cases regressed,of 6 unchanged,of 2 cases progressed after treatment of aspirin. The area and thickness of plaque were reduced to 0. 05± 0. 04cm and 0. 04 ± 0. 03cm respectively. There were no statistic difference in aspirin group. (2)The intima-media thickness of common carotid artery decreased 0. 13±0. 03mm in XFZYP group (P<0. 001 versus baseline),but there were no significant change after treatment of aspirin (P>0. 05). (3)There were no distinct change about peak systole , minimal diastole time average peak,pulsative index,resistive index in common carotid artery and internal carotid artery after treatment of XFZYP and aspirin. Conclusion: Colour Doppler ultrasonography of carotid artery provide a noninvasive,safe and valid opportunities for clinical trail. XFZYP can be useful for the treatment of carotid atherosclerosis.
Keywords:carotid atherosclerosis  Xuefuzhuyu Pill  colour Doppler ultrasonography  
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