芎芍胶囊预防冠状动脉介入治疗后再狭窄的临床研究

目的：观察芎芍胶囊预防冠状动脉介入治疗后再狭窄的临床疗效。方法：６５例经皮冠状动脉腔内成形术（ＰＴＣＡ）或（及）支架植入术成功的冠心哮胡机分为西药常规治疗（对照）组３７例和西药常规加芎芍胶囊治疗（加中药）组２８例。对患者术后６个月的心绞痛复发、血瘀证积分值变化、冠脉造影等进行随访观察。结果：加中药组心绞痛复发率显著低于对照组（Ｐ〈０．０５）。两组患者共有２８例复查冠脉造影，其中加中药线１０例中，再

Clinical Effect of Xiongshao Capsule on Preventing Restenosis Post-PTCA or/and Stenting

OBJECTIVE: To evaluate the effect of Xiongshao capsule (XSC) in preventing clinical and angiographic restenosis after coronary angioplasty or/and stenting. METHODS: Sixty-five coronary heart disease (CHD) patients with successful angioplasty or and stenting were randomly divided into the control group (37 cases, routine treatment) and the XSC group (28 cases, routine treatment plus XSC). The recurrent of angina, changing of blood stasis syndrome score (BSSS) and coronary angiography within 6 months after coronary angioplasty or/and stenting were observed. RESULTS: Recurrent angina occurred in 6 out of 28 patients in the XSC group, which was much better than that in the control group, 18 out of 37 patients (P < 0.05). Follow-up angiography was performed in 26 including 10 patients in the XSC group (restenosis was observed in 4 cases), and 16 cases in the control group (restenosis in 13 cases), there was significant difference between the XSC group and the control group (P < 0.05). For BSSS at follow-up, XSC group was much lower than that of the control group (P < 0.01). Logistic regress analysis showed the combination with XSC and the base-line BSSS were important affecting factors on the occurrence of restenosis (P < 0.05). The odds ratio of the occurrence of angiographic restenosis (BSSS > 25 to BSSS < or = 25) was 6.5. CONCLUSIONS: XSC could markedly reduce the occurrence of restenosis, recurrence of angina and improve the condition of blood stasis after coronary angioplasty or/and stenting. The severity of blood stasis syndrome was an important affecting factor on the occurrence of restenosis. BSSS > 25 can be served as one of the predicting factors of the occurrence of restenosis after coronary angioplasty or/and stenting.