养血补肾中药治疗肾虚型无排卵不孕症的临床疗效及其对卵巢、子宫动脉血流动力学参数的影响

目的 观察养血补肾中药女贞孕育汤治疗肾虚型无排卵不孕症的临床治疗效果及对卵巢、子宫动脉血流动力学参数的影响。方法 68例患者以2：1随机分组，中药组45例，服用中药女贞孕育汤，对照组23例，服用西药克罗米芬，观察月经改善情况，采用基础体温、宫颈粘液、阴道脱落细胞、血清内分泌激素和B超综合评价排卵、妊娠情况，并应用彩色多普勒超声进行子宫、卵巢血流动力学参数测定和卵泡生长、排卵、子宫内膜厚度等连续监测。结果 治疗3个周期后，并随访1年，两组促排卵率、妊娠率、流产率相近，两组均有调经作用及促进卵泡生长发育作用；中药组还有健内膜作用；在改善子宫、卵巢组织血液供应和血液循环方面，中药组明显好于对照组(P<0．05，P<0．01)。结论 养血补肾中药在突出促排卵作用的同时具有整体调节生殖系统功能的作用。

Therapeutic Effect of Chinese Herbal Medicines for Nourishing Blood and Reinforcing Shen in Treating Patients with Anovulatory Sterility of Shen-deficiency Type and Its Influence on the Hemodynamics in Ovarian and Uterine Arteries

OBJECTIVE: To observe the clinical therapeutic effect of Nuzhen Yunyu Decoction (NYD, a Chinese recipe for nourishing blood and reinforcing Shen) and its influence on the hemodynamic parameters in ovarian and uterine arteries. METHODS: Sixty-eight patients were randomly divided into two groups at the ratio of 2:1, 45 in the TCM group treated with Chinese medicine and 23 in the control group treated with clomiphene citrate. Menstrual cycle were taken as the indexes for clinical observation; basal body temperature, cervical mucus, vaginal exfoliative cells, serum hormones and B ultrasonic examination were taken as the indexes for ovulation and pregnancy assessment. The hemodynamic parameters of uterus and ovary were determined by using color Doppler ultrasonography, and the growth of follicles and ovulation, thickness of uterine endometrium were also monitored continuously. RESULTS: Results of 3 cycles treatment and 1 year follow-up study showed that the ovulation promoting rate, pregnancy rate and abortion rate in the two groups were similar, but the treated group showed better effects than that of control group, in such aspects as regulating menstruation, promoting growth and development of follicle, strengthening endometrium, improving blood supply and circulation of uterine and ovary (P < 0.05, P < 0.01). CONCLUSION: NYD has the effects of ovulation promotion and holistic regulation of reproductive system.