急性脑梗塞血瘀证与一氧化氮、内皮素相关性研究

目的探讨急性脑梗塞（ａｃｕｔｅ ｃｅｒｅｂｒａｌ ｉｎｆａｒｃｉｔｏｎ，ＡＣＩ）患者血浆一氧化氮（ｎｉｔｒｉｃ ｏｘｉｄｅ，ＮＯ）内皮素（ｅｎｄｏｔｈｅｉｌｎ，ＥＴ）与中医血瘀证的关系。方法：７３例ＡＣＩ患者分为血瘀证组５８例（其中重度１８，中度１９例，轻度２１例）和非血瘀证组１５例，并与３０名健康体检者作对照，测定血 ＥＴ含量。结果：增高，重度组与轻、中度组比较甩显著性差异（Ｐ〈０．０１），中度

Study on Relationship of Parameters of Nitric Oxide, Endothelin and Blood Stasis Syndrome in Traditional Chinese Medicine in Acute Cerebral Infarction

To explore the relationship of parameters of nitric oxide (NO), endothelin (ET) and blood stasis syndrome (BSS) of traditional Chinese medicine (TCM) in acute cerebral infarction (ACI). Methods: Seventy-three patients of ACI (ACI group) were divided into two groups by the score of BSS: BSS group (included 18 cases of serious BSS, 19 cases of moderate BSS, and 21 cases of mild BSS); and non-BSS group (15 cases); while 30 healthy subjects were taken as the control group, their NO and ET were determined. Results: Compared with the control group, the level of ET and ratio of ET/NO raised significantly in the ACI group and the BSS group (P < 0. 01 ). The levels of ET and ratio of ET/NO of mild, moderate and serious BSS increased in order, but only the serious BSS in comparing with mild, moderate group of BSS had significant difference (P < 0. 01). The NO levels of ACI group, non-BSS group in comparing with healthy Control, there was significant decrease (P < 0. 05, P < 0. 01 ). The NO concentration among the mild, moderate and serious group of BSS had insignificant difference (P > 0. 05 ). Conclusion: NO and ET participates the formation and development of ACI, owing to the disturbed NO and ET secretion by vascular, nerve cells etc., these might be the pathologic basis of BSS occurrence.