益寿调脂片抗高脂血症及动脉粥样硬化的实验研究 |
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引用本文: | 钟毅,朱秉匡,郑仕富.益寿调脂片抗高脂血症及动脉粥样硬化的实验研究[J].中国中西医结合杂志,1998,18(10):616-619. |
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作者姓名: | 钟毅 朱秉匡 郑仕富 |
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作者单位: | 广东省中医院!广州510120(钟毅),暨南大学中西医结合气血研究室(朱秉匡,郑仕富) |
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基金项目: | 国务院侨办基金资助课题!(No.93- 95 - 47) |
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摘 要: | 观察益寿调脂片对兔高脂血症,动脉粥样硬化模型中脂质人才主动脉内膜斑块形成的影响。方法:将32只家兔随机分为4组,益寿调脂片组喂高脂饲料加益寿调脂片1.59g.kg^-1.d^-1,绞股蓝总甙片组喂高脂饲料绞股蓝总甙片22.54mg.kg^-1.d^-1,高脂组喂高脂饲料,正常组喂普通饲料,6周后测定有关生化指标并进行病理形态学检查。
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关 键 词: | 益寿调脂片 高脂血症 动脉粥样硬化 |
Experimental Study of Yishou Tiaozhi Tablet on Inhibiting Hyperlipemia and Atherosclerosis |
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Authors: | Zhong Yi Zhu Bingkuang Zheng Shifu Guangdong Provincial TCM Hospital Guangzhou |
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Abstract: | OBJECTIVE: To observe the effect of Yishou Tiaozhi tablet on lipid-metabolism and aortic intimal atherosclerotic plaque coverage in rabbit's model of experimental hyperlipemia and atherosclerosis. METHODS: Thirty-two rabbits were divided randomly into four groups, group A, B, C and D, 8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of Yishou Tiaozhi tablet was fed to the group A every day; to the group B, 22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; to the group C, forage with cholesterol and lipid was fed; and to the group D, ordinary forage only. Biochemical parameters were measured and pathomorphological examination were carried out 6 weeks later. RESULTS: (1) Yishou Tiaozhi tablet obviously lowered the levels of serum TC, TG, AI, ApoB, LP (a), ox-LDL, HYP, plasma Ca2+, TXB2 and increased the levels of serum HDL-ch, ApoA1, ApoA1/APoB, plasma 6-keto-PGF1 alpha(P < 0.01). (2) Pathomorphological examination showed that in the group A aortic intimal atherosclerotic plaque area and arterial intima thickness obviously reduced, smooth muscle cell hyperplasia and elastic fibers were not seen. CONCLUSION: Yishou Tiaozhi tablet can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis. |
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Keywords: | Yishou Tiaozhi tablet hyperlipemia atherosclerosis |
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