葛根素治疗糖尿病视网膜病变的疗效观察

目的：运用活血化瘀、能经活络原理，观察葛根素对糖尿病视网膜病变患者视网膜中央动静脉血流参数及血液流变学影响。方法：３０例糖尿病视网膜病变，随机分为治疗组（１５例）和对照组（１５例）。治疗组在常规隆血糖药物治疗的同量，加用葛根素４００ｍｇ，每日１次，静脉滴注；对照组加用弥克保５００μｇ，每日１交，肌肉注射。均３周为１个疗程，连续用药２个疗程，观察用药前后血液流变学各项指标及视网膜及血沉比治疗前均有显

Observation on Efficacy of Puerarin in Treating Diabetic Retinopathy

OBJECTIVE: Using promoting blood circulation to remove stasis principle to observe arteria and vena centralis retinae blood flow indexes, and hemorrheology of diabetic retinopathy patients with Puerarin. METHODS: Thirty patients with diabetic retinopathy were randomly divided into the treated group (n = 15) and the control group (n = 15). The treated group were given Puerarin 400 mg per day intravenously dripping. The control group were given Mikebao 500 micrograms intramuscularly, once per day. Both groups were taken 3 consecutive weeks as one treatment course. Two courses later, observing hemorrheologic parameters, arteria and vena centralis retinae blood flow indexes. RESULTS: Comparing before and after treatment the RBC aggregation index, the whole blood viscosity rate, plasma viscosity rate, fibrinogen and erythrocyte sedimentation rate, have improved obviously (P < 0.05, P < 0.01). Comparing with the control group, there was significant difference (P < 0.05, P < 0.01). The difference of treated group between before and after treatment, the peak systolic velocity (PSV) of arteria centralis retinae, their end diastolic volume (EDV), the acceleration (A), the central retinal vein reflux velocity (CRV) have improved respectively. Naked eye visions were also improved, comparing with the control group, the difference was significant (P < 0.01). CONCLUSION: Puerarin can reduce blood viscosity, improve microcirculation, and plays a positive therapeutic role in diabetic retinopathy.