| 丹参对大鼠脊髓损伤后脊髓血流量及运动功能的影响 |
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| 引用本文： | 胡俊勇,刘世敬,杨远良,徐栋梁.丹参对大鼠脊髓损伤后脊髓血流量及运动功能的影响[J].中国中西医结合杂志,2003(Z1). |
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| 作者姓名： | 胡俊勇 刘世敬 杨远良 徐栋梁 |
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| 作者单位： | [1]中山医科大学第一附属医院骨科 [2]（广州510080） |
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| 摘 要： | 目的:观察丹参对大鼠脊髓损伤的保护作用。方法:14只大鼠随机分为治疗组和对照组,每组7只。采用压迫法造成大鼠 T_(11)脊髓损伤,蛛网膜下腔给药,治疗组给丹参注射液15μl,对照组给予生理盐水15μl。以激光多普勒监测伤前、伤后脊髓血流量(SCBF)的变化,并于伤后24h 测定伤段脊髓的丙二醛(MDA)含量和组织含水量,同时行后肢功能 Gale 评分和斜板试验。结果:脊髓损伤后短时间内血流量显著下降,MDA 含量显著升高,组织含水量增加,后肢功能出现明显功能障碍。与对照组比较,治疗组 SCBF 及MDA 差异有显著性;含水量及后肢功能评分差异无显著性。结论:丹参注射液能增加损伤脊髓血流量,减轻脂质过氧化反应从而对损伤脊髓有保护作用。
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| 关 键 词： | 脊髓损伤 血流量 过氧化反应 神经功能评分 丹参 |
Effect of Salvia Miltiorrhiza on Spinal Cord Blood Flow and Motor Function of Lower Limb in Rats with Spinal Cord Injury |
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| Institution: | HU Jun-yong LIU Shi-jing YANG Yuan-liang The First Affiliated Hospital of Sun Yat-sen University of Medical Sciences; Guangzhou(510080); |
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| Abstract: | Objective:To observe the protective effects of Salvia miltiorrhiza on spinal cord injury(SCI).Methods:Fourteen SD rats were randomly divided into treated group and control group,7 in each group.SCI model was made by compressiom on T_(11).The 15μl of Salvia solution and 15μl NS were given subarachnoidally via intrathecal catheterization to both groups respectively.The spinal cord blood flow (SCBF) was measured pre-injury and post-injury by laser Doppler flowmetry,malonyldialdehyde (MDA) content,water content... |
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| Keywords: | spinal cord injury blood flow lipid peroxidation Salvia miltiorrhiza |
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