六味地黄丸对激素及环磷酰胺治疗狼疮性肾炎的干预作用

目的 观察六味地黄丸对激素和环磷酰胺（CTX）治疗狼疮性肾炎（LN）的干预作用.方法 64例患者随机分为两组,两组均常规采用激素标准疗程给予泼尼松,同时给予CTX 8～12 mg/kg加入5%葡萄糖注射液500ml静脉滴注（累积总剂量≤150 mg/kg）,并予对症处理;治疗组同时加服六味地黄丸.结果 治疗组疗效显著优于对照组（P＜0.05）;24 h尿蛋白定量、血浆白蛋白、血肌酐、血沉、补体C3等指标两组治疗后均显著改善（P＜0.01）,除血肌酐外,其他指标治疗组均优于对照组（P＜0.05或P＜0.01）;复发率治疗组低于对照组（P＜0.05）;不良反应发生率治疗组显著低于对照组（P＜0.01）.结论 六味地黄丸能显著提高激素及CTX对LN的疗效,减少其复发,并能对抗激素及CTX的不良反应.

Intervention of Liuwei Dihuang Pill on Lupus Nephropathy Treated with Cylophosphamide and Glucocorticoids

OBJECTIVE: To investigate the intervening effect of Liuwei Dihuang pill (LWDH) on lupus nephropathy (LN) treated with glucocorticoids and cyclophosphamide (CTX). METHODS: Sixty-four patients were randomly divided into two groups, all patients were treated by conventional treatment, using prednisone in standard program, and CTX in a daily dose of 8 - 12 mg/kg, accumulated dose < or = 150 mg/kg, by adding into 500 ml of 5% glucose in saline through intravenous dripping, as well as the symptomatic treatment. Patients in the treated group were given LWDH additionally. RESULTS: The curative effect in the treated group was significantly superior to that in the control group (P < 0.05). Laboratory indexes, including urinary protein, plasma protein and serum creatinine (SCr), erythrocyte sedimentation rate (ESR), complement C3, etc. were significantly improved in both groups (P < 0.01), but all the improvement, except that of SCr, in the treated group were superior to those in the control group respectively (P <0.05 or P <0.01). Besides, the recurrent rate and incidence rate of adverse reaction in the treated group was significant lower than those in the control group (P < 0.05 and P < 0.01). CONCLUSION: LWDH can significantly enhance the therapeutic effect of CTX and glucocorticoids on LN, decrease the recurrence and shows advantage in counteracting against the adverse effects of glucocorticoids and CTX.