中药艾灵颗粒对HIV/AIDS患者免疫重建的影响 |
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引用本文: | 危剑安,孙利民,陈宇霞,薛柳华,苏小游,黄霞珍,白文山,宋春鑫,周伟,金燕.中药艾灵颗粒对HIV/AIDS患者免疫重建的影响[J].中国中西医结合杂志,2006,26(4):319-321. |
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作者姓名: | 危剑安 孙利民 陈宇霞 薛柳华 苏小游 黄霞珍 白文山 宋春鑫 周伟 金燕 |
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作者单位: | 1. 中国中医科学院广安门医院,北京,100053 2. 中国疾病预防与控制中心 |
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基金项目: | 国家自然科学基金资助项目(No.30371822) |
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摘 要: | 目的 拟通过对艾滋病感染/艾滋病(HIV/AIDS)患者进行益气活血中药的干预,初步探索益气活血中药艾灵颗粒治疗艾滋病的可能作用机理。方法 21例HIV/AIDS患者采用益气活血中药艾灵颗粒(主要由女贞子、黄芩、黄芪、土鳖虫等组成)治疗,每次20g,每日2次,疗程4个月,记录治疗前后症状、体征积分,以流式细胞技术检测其T细胞亚群(CD3、CD4、CD8)、白细胞介素-2(IL-2),以RT-PCR法测定病毒栽量,并检测安全性指标(ALT、Cr、体重)。结果 治疗后症状、体征积分较治疗前下降,其中乏力、纳呆、自汗、皮疹差异有显著性(P〈0.05),有效率为61.9%;CD4计数和IL-2分别由治疗前的(308.29±150.66)个/μl和(13.19±5.93)ng/L升高为治疗后的(336.50±148.94)个/μl和(15.144-5.14)ng/L(P〈0.05),病毒载量虽有下降,但差异无显著性;安全性指标(ALT、Cr、体重)均保持稳定(P〉0.05)。结论 益气活血中药艾灵颗粒可显著改善艾滋病患者的症状,提高免疫功能,并在一定程度上抑制HIV的复制,或使其处于稳定状态,且未见明显毒副反应。
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关 键 词: | 益气活血中药 艾滋病感染/艾滋病 免疫重建 白细胞介素-2 |
收稿时间: | 2005-08-29 |
修稿时间: | 2006-01-10 |
Effects of Ailing Granule on Immuno-reconstruction in HIV/AIDS Patients |
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Authors: | WEI Jian-an SUN Li-min CHEN Yu-xia |
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Abstract: | OBJECTIVE: To explore the possible mechanism of Ailing Granule (AG, a Chinese herbal preparation for nourishing Qi and activating blood circulation) in intervening HIV/AIDS. METHODS: Twenty-one HIV/AIDS patients were orally administered with AG (mainly composed of Fructus Ligustri lucidi, Radix Scutellariae, Radix Astragalus and Eupolyphaga et polyphage) by 20g, twice a day for 4 months. Their symptoms and signs were scored, T cell subgroup (CD3, CD4, CD8) and interleukin-2 (IL-2) were detected with flow-cytometry, and viral load determined with RT-PCR, as well as some indexes for safety evaluation, including ALT, Cr and BW were observed before and after treatment. RESULTS: After treatment, the symptom and sign score of patients lowered, among them the scores of fatigue, anorexia, spontaneous sweating and skin rash reduced with difference statistically (P < 0.05); the total effective rate was 61.9%; CD4 count and IL-2 level increased from 308.29 +/- 150.66/microl and 13.19 +/- 5.93 ng/L to 336.50 +/- 148.94/micro1 and 15.14 +/- 5.14 ng/L respectively( P < 0.05); while the viral load lowered but showed no significant difference. All the indexes of safety measured kept unwavering during treatment(P > 0.05). CONCLUSION: AG could significantly alleviate the symptoms of HIV/AIDS patients, improve their immune function, inhibit HIV reproduction to a certain extent or keep it stable. No obvious toxic or adverse reaction was seen. |
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Keywords: | nourishing Qi and activating blood circulation HIV/AIDS immuno-reconstruction interleukin-2 |
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